Annals of Oncology

News:

When rules about ‘orphan drugs’ go wrong, costs rise
Ann Oncol 13: 1327-1328; doi:10.1093/annonc/mdf336
[Extract] [FREE Full Text] [PDF] [Request Permissions]

Editorial:

C. S. Portlock

Dose density and dose intensity: where does CHOP go from here?
Ann Oncol 13: 1329-1330; doi:10.1093/annonc/mdf238
[Extract] [FREE Full Text] [PDF] [Request Permissions]

Review:

I. Goethals, O. De Winter, P. De Bondt, J. De Sutter, R. Dierckx, and C. Van De Wiele

The clinical value of nuclear medicine in the assessment of irradiation-induced and anthracycline-associated cardiac damage
Ann Oncol 13: 1331-1339; doi:10.1093/annonc/mdf318
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

Original articles:

Hematologic malignancies:

M. Balzarotti, M. Spina, B. Sarina, M. Magagnoli, L. Castagna, I. Milan, C. Ripa, F. Latteri, D. Bernardi, A. Bertuzzi, A. Nozza, M. Roncalli, E. Morenghi, U. Tirelli, and A. Santoro

Intensified CHOP regimen in aggressive lymphomas: maximal dose intensity and dose density of doxorubicin and cyclophosphamide
Ann Oncol 13: 1341-1346; doi:10.1093/annonc/mdf242
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

K. Itoh, T. Ohtsu, H. Fukuda, Y. Sasaki, M. Ogura, Y. Morishima, T. Chou, K. Aikawa, N. Uike, F. Mizorogi, T. Ohno, S. Ikeda, T. Sai, M. Taniwaki, F. Kawano, M. Niimi, T. Hotta, M. Shimoyama, and K. Tobinai

Randomized phase II study of biweekly CHOP and dose-escalated CHOP with prophylactic use of lenograstim (glycosylated G-CSF) in aggressive non-Hodgkin’s lymphoma: Japan Clinical Oncology Group Study 9505
Ann Oncol 13: 1347-1355; doi:10.1093/annonc/mdf287
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

K. Spaepen, S. Stroobants, P. Dupont, P. Vandenberghe, J. Thomas, T. de Groot, J. Balzarini, C. De Wolf-Peeters, L. Mortelmans, and G. Verhoef

Early restaging positron emission tomography with ¹⁸F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin’s lymphoma
Ann Oncol 13: 1356-1363; doi:10.1093/annonc/mdf256
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

P. L. Zinzani, F. Gherlinzoni, S. Storti, A. Zaccaria, E. Pavone, L. Moretti, P. Gentilini, L. Guardigni, A. De Renzo, P. P. Fattori, B. Falini, V. M. Lauta, D. Mannina, F. Zaja, P. Mazza, E. Volpe, F. Lauria, E. Aitini, F. Ciccone, M. Tani, V. Stefoni, L. Alinari, M. Baccarani, and S. Tura

Randomized trial of 8-week versus 12-week VNCOP-B plus G-CSF regimens as front-line treatment in elderly aggressive non-Hodgkin’s lymphoma patients
Ann Oncol 13: 1364-1369; doi:10.1093/annonc/mdf208
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

P. J. Bierman, J. C. Lynch, R. G. Bociek, V. L. Whalen, A. Kessinger, J. M. Vose, and J. O. Armitage

The International Prognostic Factors Project score for advanced Hodgkin’s disease is useful for predicting outcome of autologous hematopoietic stem cell transplantation
Ann Oncol 13: 1370-1377; doi:10.1093/annonc/mdf228
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

Breast cancer:

R. Arriagada, M. Spielmann, S. Koscielny, T. Le Chevalier, T. Delozier, M. Ducourtieux, T. Tursz, and C. Hill

Patterns of failure in a randomized trial of adjuvant chemotherapy in postmenopausal patients with early breast cancer treated with tamoxifen
Ann Oncol 13: 1378-1386; doi:10.1093/annonc/mdf299
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

S. B. Schagen, M. J. Muller, W. Boogerd, R. M. Rosenbrand, D. van Rhijn, S. Rodenhuis, and F. S. A. M. van Dam

Late effects of adjuvant chemotherapy on cognitive function: a follow-up study in breast cancer patients
Ann Oncol 13: 1387-1397; doi:10.1093/annonc/mdf241
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

C. Bozzetti, R. Nizzoli, A. Guazzi, M. Flora, C. Bassano, P. Crafa, N. Naldi, and S. Cascinu

HER-2/neu amplification detected by fluorescence in situ hybridization in fine needle aspirates from primary breast cancer
Ann Oncol 13: 1398-1403; doi:10.1093/annonc/mdf217
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

R. Arriagada, M. G. Lê, G. Contesso, J. M. Guinebretière, F. Rochard, and M. Spielmann

Predictive factors for local recurrence in 2006 patients with surgically resected small breast cancer
Ann Oncol 13: 1404-1413; doi:10.1093/annonc/mdf227
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

P. M. Ellis, P. N. Butow, and M. H. N. Tattersall

Informing breast cancer patients about clinical trials: a randomized clinical trial of an educational booklet
Ann Oncol 13: 1414-1423; doi:10.1093/annonc/mdf255
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

Gastrointestinal tumors:

C. Carnaghi, L. Rimassa, I. Garassino, P. A. Zucali, G. Masci, M. Fallini, E. Morenghi, and A. Santoro

Irinotecan and raltitrexed: an active combination in advanced colorectal cancer
Ann Oncol 13: 1424-1429; doi:10.1093/annonc/mdf229
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

Å. Berglund, D. Molin, A. Larsson, R. Einarsson, and B. Glimelius

Tumour markers as early predictors of response to chemotherapy in advanced colorectal carcinoma
Ann Oncol 13: 1430-1437; doi:10.1093/annonc/mdf220
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

V. Bazan, M. Migliavacca, I. Zanna, C. Tubiolo, N. Grassi, M. A. Latteri, M. La Farina, I. Albanese, G. Dardanoni, S. Salerno, R. M. Tomasino, R. Labianca, N. Gebbia, and A. Russo

Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype
Ann Oncol 13: 1438-1446; doi:10.1093/annonc/mdf226
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

M. Colombino, A. Cossu, A. Manca, M. F. Dedola, M. Giordano, F. Scintu, A. Curci, A. Avallone, G. Comella, M. Amoruso, A. Margari, G. M. Bonomo, M. Castriota, F. Tanda, and G. Palmieri

Prevalence and prognostic role of microsatellite instability in patients with rectal carcinoma
Ann Oncol 13: 1447-1453; doi:10.1093/annonc/mdf240
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

Lung cancer:

J. P. Sculier, J. J. Lafitte, J. Lecomte, T. Berghmans, J. Thiriaux, O. Van Cutsem, A. Efremidis, V. Ninane, M. Paesmans, P. Mommen, and J. Klastersky

A phase II randomised trial comparing the cisplatin–etoposide combination chemotherapy with or without carboplatin as second-line therapy for small-cell lung cancer
Ann Oncol 13: 1454-1459; doi:10.1093/annonc/mdf244
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

Urogenital tumors:

S. Négrier, B. Escudier, F. Gomez, J.-Y. Douillard, A. Ravaud, C. Chevreau, M. Buclon, D. Pérol, and C. Lasset

Prognostic factors of survival and rapid progression in 782 patients with metastatic renal carcinomas treated by cytokines: a report from the Groupe Français d’Immunothérapie
Ann Oncol 13: 1460-1468; doi:10.1093/annonc/mdf257
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

Phase I and pharmacokinetics:

T. R. J. Evans, G. Pentheroudakis, J. Paul, A. McInnes, R. Blackie, N. Raby, R. Morrison, G. M. Fullarton, M. Soukop, and A. C. McDonald

A phase I and pharmacokinetic study of capecitabine in combination with epirubicin and cisplatin in patients with inoperable oesophago-gastric adenocarcinoma
Ann Oncol 13: 1469-1478; doi:10.1093/annonc/mdf243
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

S. Faivre, T. Le Chevalier, C. Monnerat, F. Lokiec, S. Novello, J. Taieb, P. Pautier, C. Lhommé, P. Ruffié, L. Kayitalire, J.-P. Armand, and E. Raymond

Phase I–II and pharmacokinetic study of gemcitabine combined with oxaliplatin in patients with advanced non-small-cell lung cancer and ovarian carcinoma
Ann Oncol 13: 1479-1489; doi:10.1093/annonc/mdf219
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

N. Kemeny, W. Tong, M. Gonen, J. Stockman, C. Di Lauro, J. Teitcher, P. White, C. Price, L. Saltz, S. Sharma, and M. A. Graham

Phase I study of weekly oxaliplatin plus irinotecan in previously treated patients with metastatic colorectal cancer
Ann Oncol 13: 1490-1496; doi:10.1093/annonc/mdf247
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

Epidemiology:

H. Darwish, I. E. Trejo, I. Shapira, S. Oweineh, M. Sughayer, L. Baron, E. Aljadeff, M. Silbermann, W. Sweidan, D. Zilberg, Z. Halpern, H. Hibshoosh, and N. Arber

Fighting colorectal cancer: molecular epidemiology differences among Ashkenazi and Sephardic Jews and Palestinians
Ann Oncol 13: 1497-1501; doi:10.1093/annonc/mdf230
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

Clinical case:

M. Fiegl, R. Greil, C. Pechlaner, J. Krugmann, and S. Dirnhofer

Intravascular large B-cell lymphoma with a fulminant clinical course: a case report with definite diagnosis post mortem
Ann Oncol 13: 1503-1506; doi:10.1093/annonc/mdf214
[Abstract] [FREE Full Text] [PDF] [Request Permissions]

Letters to the Editor:

P. Dreger

Allogeneic stem cell transplantation for patients with resistant high-grade lymphoma: what is the potential of reduced-intensity conditioning?
Ann Oncol 13: 1507; doi:10.1093/annonc/mdf225
[Extract] [FREE Full Text] [PDF] [Request Permissions]

B. Fervers, T. Philip, and G. P. Browman

Critical appraisal of the Minimal Clinical Recommendations (MCR) of the European Society for Medical Oncology (ESMO): challenges for a European framework for the development of clinical practice guidelines
Ann Oncol 13: 1507-1509; doi:10.1093/annonc/mdf246
[Extract] [FREE Full Text] [PDF] [Request Permissions]

R. Stahel

Reply to the Letter to the Editor "Critical appraisal of the Minimal Clinical Recommendations (MCR) of the European Society for Medical Oncology (ESMO): challenges for a European framework for the development of clinical practice guidelines", by B. Fervers, T. Philip and G. P. Browman (Ann Oncol 2002; 13: 1507–1509)
Ann Oncol 13: 1509; doi:10.1093/annonc/mdf330
[Extract] [FREE Full Text] [PDF] [Request Permissions]

B. Iacopetta

A biological perspective on the selection of stage II colorectal cancer patients for adjuvant chemotherapy
Ann Oncol 13: 1510; doi:10.1093/annonc/mdf245
[Extract] [FREE Full Text] [PDF] [Request Permissions]

Book reviews:

M. Brada

M. Prados (ed). Brain Cancer
Ann Oncol 13: 1511; doi:10.1093/annonc/mdf250
[Extract] [FREE Full Text] [PDF] [Request Permissions]

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.