Annals of Oncology

News:

President Bush nominates top White House aide as FDA chief
Ann Oncol 13: 1693-1694; doi:10.1093/annonc/mdf348
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Editorials:

J. S. Tobias and R. D. Hamilton

Prospective clinical trials as a model for patient-centred care
Ann Oncol 13: 1695-1696; doi:10.1093/annonc/mdf341
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D. E. Brenner

New paradigms in oncological therapeutics: redefining combination chemotherapy
Ann Oncol 13: 1697-1698; doi:10.1093/annonc/mdf349
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Review:

J. Goffin and E. Eisenhauer

DNA methyltransferase inhibitors—state of the art
Ann Oncol 13: 1699-1716; doi:10.1093/annonc/mdf314
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Original articles:

Breast cancer:

E. Heidemann, H. Stoeger, R. Souchon, W.-D. Hirschmann, H. Bodenstein, C. Oberhoff, J. T. Fischer, M. Schulze, M. Clemens, R. Andreesen, M. Mahlke, M. König, A. Scharl, K. Fehnle, and M. Kaufmann

Is first-line single-agent mitoxantrone in the treatment of high-risk metastatic breast cancer patients as effective as combination chemotherapy? No difference in survival but higher quality of life were found in a multicenter randomized trial
Ann Oncol 13: 1717-1729; doi:10.1093/annonc/mdf306
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G. Mustacchi, M. Muggia, S. Milani, R. Ceccherini, M. L. Leita, and C. Dellach

A phase II study of cisplatin and vinorelbine in patients with metastatic breast cancer
Ann Oncol 13: 1730-1736; doi:10.1093/annonc/mdf290
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H. Gogas, C. Papadimitriou, H. P. Kalofonos, D. Bafaloukos, G. Fountzilas, D. Tsavdaridis, A. Anagnostopoulos, A. Onyenadum, P. Papakostas, T. Economopoulos, C. Christodoulou, P. Kosmidis, and C. Markopoulos

Neoadjuvant chemotherapy with a combination of pegylated liposomal doxorubicin (Caelyx^®) and paclitaxel in locally advanced breast cancer: a phase II study by the Hellenic Cooperative Oncology Group
Ann Oncol 13: 1737-1742; doi:10.1093/annonc/mdf284
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J.-L. Merlin, M. Barberi-Heyob, and N. Bachmann

In vitro comparative evaluation of trastuzumab (Herceptin^®) combined with paclitaxel (Taxol^®) or docetaxel (Taxotere^®) in HER2-expressing human breast cancer cell lines
Ann Oncol 13: 1743-1748; doi:10.1093/annonc/mdf263
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Gynecologic tumors:

J. Sehouli, D. Stengel, G. Oskay, O. Camara, H.-J. Hindenburg, P. Klare, J. Blohmer, G. Heinrich, D. Elling, P. Ledwon, and W. Lichtenegger

A phase II study of topotecan plus gemcitabine in the treatment of patients with relapsed ovarian cancer after failure of first-line chemotherapy
Ann Oncol 13: 1749-1755; doi:10.1093/annonc/mdf294
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Gastrointestinal tumors:

J. Feliu, R. Mel, P. Borrega, L. López Gómez, P. Escudero, J. Dorta, J. Castro, S. E. Vázquez-Estévez, M. Bolaños, E. Espinosa, and M. González Barón

Phase II study of a fixed dose-rate infusion of gemcitabine associated with uracil/tegafur in advanced carcinoma of the pancreas
Ann Oncol 13: 1756-1762; doi:10.1093/annonc/mdf286
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J. S. Waters, D. Tait, D. Cunningham, A. R. Padhani, M. E. Hill, S. Falk, F. Lofts, A. Norman, J. Oates, and A. Hill

A multicentre phase II trial of primary chemotherapy with cisplatin and protracted venous infusion 5-fluorouracil followed by chemoradiation in patients with carcinoma of the oesophagus
Ann Oncol 13: 1763-1770; doi:10.1093/annonc/mdf301
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T. S. Yang, C. H. Wang, R. K. Hsieh, J. S. Chen, and M. C. Fung

Gemcitabine and doxorubicin for the treatment of patients with advanced hepatocellular carcinoma: a phase I–II trial
Ann Oncol 13: 1771-1778; doi:10.1093/annonc/mdf303
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H. M. Chang, K. H. Jung, T.-Y. Kim, W. S. Kim, H.-K. Yang, K. U. Lee, K. J. Choe, D. S. Heo, Y.-J. Bang, and N. K. Kim

A phase III randomized trial of 5-fluorouracil, doxorubicin, and mitomycin C versus 5-fluorouracil and mitomycin C versus 5-fluorouracil alone in curatively resected gastric cancer
Ann Oncol 13: 1779-1785; doi:10.1093/annonc/mdf302
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Hematologic malignancies:

A. Foss Abrahamsen, A. Andersen, O. Nome, A. B. Jacobsen, H. Holte, J. Foss Abrahamsen, and S. Kvaløy

Long-term risk of second malignancy after treatment of Hodgkin’s disease: the influence of treatment, age and follow-up time
Ann Oncol 13: 1786-1791; doi:10.1093/annonc/mdf289
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T. Saito, Y. Matsuno, R. Tanosaki, T. Watanabe, Y. Kobayashi, and K. Tobinai

T-cell neoplasms: a clinicopathological study of 11 cases
Ann Oncol 13: 1792-1798; doi:10.1093/annonc/mdf293
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Urogenital tumors:

R. J. Motzer, A. Rakhit, J. Thompson, H. Gurney, P. Selby, R. Figlin, S. Negrier, S. Ernst, M. Siebels, M. Ginsberg, K. Rittweger, and L. Hooftman

Phase II trial of branched peginterferon- 2a (40 kDa) for patients with advanced renal cell carcinoma
Ann Oncol 13: 1799-1805; doi:10.1093/annonc/mdf288
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Miscellaneous tumors:

E. Baudin, C. Docao, C. Gicquel, G. Vassal, A. Bachelot, A. Penfornis, and M. Schlumberger

Use of a topoisomerase I inhibitor (irinotecan, CPT-11) in metastatic adrenocortical carcinoma
Ann Oncol 13: 1806-1809; doi:10.1093/annonc/mdf291
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Phase I and pharmacokinetics:

D. Rischin, S. P. Ackland, J. Smith, M. B. Garg, S. Clarke, M. J. Millward, G. C. Toner, and J. Zalcberg

Phase I and pharmacokinetic study of docetaxel in combination with epirubicin and cyclophosphamide in advanced cancer: dose escalation possible with granulocyte colony-stimulating factor, but not with prophylactic antibiotics
Ann Oncol 13: 1810-1818; doi:10.1093/annonc/mdf305
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P. M. Fracasso, J. S. Rader, R. Govindan, T. J. Herzog, M. A. Arquette, A. Denes, D. G. Mutch, J. Picus, B. R. Tan, C. L. Fears, S. A. Goodner, and S. L. Sun

Phase I study of rubitecan and gemcitabine in patients with advanced malignancies
Ann Oncol 13: 1819-1825; doi:10.1093/annonc/mdf342
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Clinical case:

M. Ponzoni, M. R. Terreni, F. Ciceri, A. J. M. Ferreri, S. Gerevini, N. Anzalone, M. Valle, S. Pizzolito, and G. Arrigoni

Primary brain CD30+ ALK1+ anaplastic large cell lymphoma (‘ALKoma’): the first case with a combination of ‘not common’ variants
Ann Oncol 13: 1827-1832; doi:10.1093/annonc/mdf300
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Letters to the Editor:

A. Chehal, J. H. Haidar, R. Jabbour, B. Yammout, and A. Bazarbachi

Obstructive sleep apnea secondary to chronic lymphocytic leukemia
Ann Oncol 13: 1833; doi:10.1093/annonc/mdf277
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A. Vora, M. Bhutani, A. Sharma, and V. Raina

Severe tumor lysis syndrome during treatment with STI 571 in a patient with chronic myelogenous leukemia accelerated phase
Ann Oncol 13: 1833-1834; doi:10.1093/annonc/mdf304
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Book reviews:

M. Rabaglio

P.J. Eifel, C. Levenback (eds). Cancer of the Female Lower Genital Tract
Ann Oncol 13: 1835; doi:10.1093/annonc/mdf210
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M. Mandalà and S. Barni

A. Manni, M.F. Verderame (eds). Selective Estrogen Receptor Modulators: Research and Clinical Applications
Ann Oncol 13: 1835-1836; doi:10.1093/annonc/mdf292
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