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Annals of Oncology Advance Access published online on October 26, 2008
Annals of Oncology, doi:10.1093/annonc/mdn645
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© The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

letter to the editor

Genetic testing for UGT1A1*28 and *6 in Japanese patients who receive irinotecan chemotherapy

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Polymorphisms of the UDP-glucuronosyltransferase (UGT) 1A1 gene, such as UGT1A1*28 and UGT1A1*6, can cause severe neutropenia and diarrhea in patients who receive irinotecan [1, 2]. Homozygosity for UGT1A1*28 is associated with less efficient glucuronidation of SN-38, the active metabolite of irinotecan, resulting in increased plasma SN-38 concentrations. Four pharmacogenetic trials have demonstrated an association between UGT1A1*28 genotype and irinotecan-induced hematologic . . . [Full Text of this Article]

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K. Araki1, W. Ichikawa1, T. Miya1, M. Narabayashi1, K. Kawara1, M. Sugiyama1, T. Hirose1, Y. Ando1 and Y. Sasaki1,2,*

1 Department of Medical Oncology, Saitama International Medical Center-Comprehensive Cancer Center, Saitama Medical University
2 Project Research Laboratory, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan

* (E-mail ysasaki@saitama-med.ac.jp)


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