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Annals of Oncology Advance Access published online on May 13, 2008
Annals of Oncology, doi:10.1093/annonc/mdn286
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© The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

letter to the editor

COX-2 targeting in cancer: a new beginning?

The first 10% of the full text of this article appears below.

Cyclo-oxygenase-2 (COX-2), the inducible enzyme catalyzing the rate-limiting step in the conversion of arachidonic acid into eicosanoids, is overexpressed in a wide variety of malignancies and associates with poor prognostic features [1]. Consequently, selective COX-2 inhibitors have been explored as therapeutic or . . . [Full Text of this Article]

M. Milella, G. Metro, A. Gelibter, S. M. Pino, F. Cognetti and A. Fabi*

Division of Medical Oncology, Regina Elena Cancer Center, Rome, Italy

* E-mail: alessandra.fabi@virgilio.it


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