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Annals of Oncology Advance Access published online on February 13, 2008
Annals of Oncology, doi:10.1093/annonc/mdm606
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© The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Does body mass index affect progression-free or overall survival in patients with ovarian cancer? Results from SCOTROC I trial

S. V. Barrett1,*, J. Paul2, A. Hay2, P. A. Vasey3, S. B. Kaye4, R. M. Glasspool1 On behalf of the Scottish Gynaecological Cancer Trials Group

1 Department of Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow
2 Cancer Research UK Clinical Trials Unit, Beatson West of Scotland Cancer Centre, Glasgow, UK
3 Department of Medical Oncology, University of Queensland, Brisbane, Australia
4 Section of Medicine, The Institute of Cancer Research, London, UK

* Correspondence to: Dr S. V. Barrett, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow G12 0YN, UK. Tel: +44-141-301-7000; Fax: +44-141-301-7124; E-mail: sophie.barrett{at}nhs.net

Background: Previous studies have indicated an association between obesity and poor survival in several tumour types, including ovarian cancer. We sought to test the hypothesis that obesity reduces survival in a large, well-characterised and relatively homogeneous cohort of ovarian cancer patients.

Patients and methods: The relationship between body mass index (BMI) and overall survival (OS) and progression-free survival (PFS) in 1067 patients participating in the Scottish Randomised Trial in Ovarian Cancer I trial was assessed. All patients received first-line carboplatin/taxane chemotherapy. The dose of carboplatin was determined by a measured glomerular filtration rate (GFR), ensuring accurate dosing in all categories of BMI and the dose of taxane was not capped. Patients were assigned to one of four categories: underweight (BMI < 18.5), ideal weight (BMI 18.5–24.9), overweight (BMI 25–29.9) or obese (BMI ≥ 30).

Results: There were neither statistically significant differences in PFS or OS between these four groups nor were there any differences in taxane or carboplatin dose intensity. Furthermore, there was no association between BMI and tumour stage or grade at presentation, or completeness of debulking surgery.

Conclusions: Obese patients with epithelial ovarian cancer do not have a poorer prognosis, provided that they receive optimal doses of chemotherapy based on measured GFR and actual body weight.

body mass index, ovarian cancer, survival

Received for publication October 4, 2007. Revision received December 18, 2007. Accepted for publication December 19, 2007.


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