Annals of Oncology Advance Access published online on December 4, 2007
Annals of Oncology, doi:10.1093/annonc/mdm549
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© 2007 European Society for Medical Oncology
Weight change and cancer risk in a cohort of more than 65 000 adults in Austria
1 Institute of Epidemiology, University of Ulm, Helmholtzstrasse, Germany
2 Agency for Preventive and Social Medicine, Bregenz
3 Department of Medical Statistics, Informatics and Health Economics, Innsbruck, Medical University
4 Cancer Registry of Tyrol, Department of Clinical Epidemiology of the Tyrolean State Hospitals Ltd, Innsbruck, Austria
5 Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
* Correspondence to: Dr K. Rapp, Institute of Epidemiology, University of Ulm, Helmholtzstrasse 22, 89081 Ulm, Germany. Tel: +49-731-5031070; Fax: +49-731-5031069; E-mail: kilian.rapp{at}uni-ulm.de
Background: To investigate relations between weight loss or weight gain and the incidence of cancer.
Patients and methods: Weight change was assessed in a population-based cohort of >65 000 Austrian adults (28 711 men and 36 938 women) for a period of 7 years, after which participants were followed for incident cancers over 8 years on average. Incident cancers (other than nonmelanoma skin cancers) were ascertained by a population-based cancer registry (n = 3128). Cox proportional hazards models were used to estimate hazard rate ratios (HRs) stratified by age and adjusted for smoking, occupational group, blood glucose and body mass index at baseline.
Results: In both men and women, neither weight loss nor weight gain was clearly associated with the incidence of all cancers combined. Weight loss (>0.10 kg/m2/year) was inversely associated with colon cancer in men [HR 0.50; 95% confidence interval (CI) 0.29–0.87], while high weight gain (
0.50 kg/m2/year) was inversely associated with prostate cancer (HR 0.43; 95% CI 0.24–0.76). Among women, high weight gain was positively associated with ovarian cancer (HR 2.48; 95% CI 1.05–5.85).
Conclusion: These findings indicate that recent weight change may influence the incidence of several types of cancer.
colon cancer, epidemiology, ovarian cancer, prostate cancer, weight change
Received for publication September 12, 2007. Revision received October 30, 2007. Accepted for publication October 31, 2007.
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