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Annals of Oncology Advance Access published online on December 20, 2007
Annals of Oncology, doi:10.1093/annonc/mdm501
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© 2007 European Society for Medical Oncology

Phase II study of pemetrexed in combination with carboplatin in patients with malignant pleural mesothelioma (MPM)

B. Castagneto1, M. Botta1, E. Aitini2, F. Spigno7, D. Degiovanni1, O. Alabiso4, M. Serra3, A. Muzio1, R. Carbone5, R. Buosi4, V. Galbusera3, E. Piccolini6, L. Giaretto1, L. Rebella3 and M. Mencoboni3,*

1 Department of Oncology, Novi Ligure Hospital, viale Giolitti, Novi Ligure (AL)
2 Department of Oncology, Ospedale ‘C. Poma’, viale Albertoni, Mantova
3 Department of Oncology, Ospedale ‘Villa Scassi’, Corso Onofrio Scassi, Genova
4 Department of Oncology, Ospedale Maggiore della Carità, Corso Mazzini, Novara
5 Department of Pneumology, Ospedale Regionale di Aosta, viale Ginevra, Aosta
6 Department of Pneumology, Ospedale ‘S. Spirito’, viale Giolitti, Casale Monferrato (AL)
7 Occupational Medicine Unit, University of Genoa, Largo Rosanna Benzi, Genova, Italy

* Correspondence to: Dr M. Mencoboni, via Giovanni Torti 6/13, 16143 Genoa, Italy. Tel: +39-010-4102639; Fax: +39-010-8630625; E-mail: manlio.mencoboni{at}fastwebnet.it

Background: The aim of this study was to evaluate the activity and toxicity of pemetrexed and carboplatin combination as first-line chemotherapy in malignant pleural mesothelioma (MPM).

Patients and methods: Patients with measurable advanced MPM and a zero to two Eastern Cooperative Oncology Group (ECOG) performance status (PS) were enrolled. The schedule was pemetrexed 500 mg/m2 in combination with carboplatin area under the curve 5, every 21 days. In all, 76 patients were treated. Median age was 65 years; median ECOG PS was zero.

Results: Grade 3 hematological toxicity according to World Health Organization criteria was seen in 36 (47.3%) patients; grade 4 hematological toxicity in 5 (6.5%) patients. There were 16 (21%) partial responses and 3 (4%) complete responses, for an overall response rate of 19 (25%) [95% confidence interval (CI) 15.3–34.7]. In all, 29 (39%) (95% CI 28–48) patients reported stable disease. The median survival was estimated at 14 months.

Conclusion: This combination of carboplatin and pemetrexed is moderately active and the toxicity is acceptable.

chemotherapy, mesothelioma, pemetrexed

Received for publication June 2, 2007. Revision received September 12, 2007. Accepted for publication September 14, 2007.


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