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Annals of Oncology Advance Access published online on November 27, 2007
Annals of Oncology, doi:10.1093/annonc/mdm485
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© 2007 European Society for Medical Oncology

Gastric extranodal marginal zone B-cell lymphomas of MALT type exclusively express toll-like receptor 4 in contrast to other lymphomas infiltrating the stomach

P. Adam1,*, B. Schmausser1, M. Göbeler-Kolve2, H. K. Müller-Hermelink1 and M. Eck1

1 Pathologisches Institut
2 Medizinische Poliklinik, Universität Würzburg, Würzburg, Germany

* Correspondence to: Dr P. Adam, Pathologisches Institut, Universität Würzburg, Josef-Schneider-Street 2, 97080 Würzburg, Germany. Tel: +49-931-201-47877; Fax: +49-931-201-47505; E-mail: patrick.adam{at}mail.uni-wuerzburg.de

Background: Development and growth of extranodal marginal zone B-cell lymphomas (eMZBCLs) of mucosa-associated lymphoid tissue (MALT) type are thought to be highly dependent on Helicobacter pylori and autoantigens. Receptors mediating these effects are not characterised so far. Toll-like receptors (TLRs) recognise bacterial proteins and autoantigens, which results in inflammatory reactions and influences tumour development and growth.

Materials and methods: TLR4, 5 and 9 expressions were evaluated by immunohistology and confocal microscopy in gastric eMZBCL in comparison to other lymphomas infiltrating the stomach.

Results: TLR4 was exclusively expressed on the cell surface in all eMZBCL (n = 19) and not in chronic lymphocytic leukaemia (CLL, n = 12) or mantle cell lymphoma (MCL, n = 10). TLR5 was strongly expressed in CLL and weak in some eMZBCL (15 of 19), but not in MCL. TLR4, 5 and 9 were negative in all the three lymphoma entities.

Conclusions: Exclusive TLR4 expression may enable eMZBCL to interact with H. pylori and autoantigens. Blockade of TLR4 might be a new approach for therapy of eMZBCL of MALT type.

gastric lymphoma, MALT lymphoma, TLR4, 5 and 9, toll-like receptors

Received for publication February 6, 2007. Revision received September 16, 2007. Accepted for publication September 17, 2007.


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