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Annals of Oncology Advance Access published online on October 17, 2007
Annals of Oncology, doi:10.1093/annonc/mdm457
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© 2007 European Society for Medical Oncology

Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma

E.-K. Song1,4, S.-Y. Kim1, T. M. Kim1, K.-W. Lee1, T. Yun1, I.-I. Na1, H. Shin1, S. H. Lee1, D. W. Kim1, S. I. Khwarg2 and D. S. Heo1,3,*

1 Department of Internal Medicine
2 Department of Ophthalmology
3 Cancer Research Institute, Seoul National University College of Medicine, Seoul
4 Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea

* Correspondence to: Dr D. S. Heo, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea. Tel: +82-2-2072-2857; Fax: +82-2-742-6689; E-mail: heo1013{at}snu.ac.kr

Background: Radiotherapy is commonly used as a first-line treatment for localized ocular adnexal extranodal marginal zone B-cell lymphoma (EMZBL), despite its ophthalmologic complications. This study was undertaken to analyze the efficacy of first-line chemotherapy in treating EMZBL. Chemotherapy was followed by radiotherapy only in recurrent cases.

Patients and methods: Twenty-one patients with histologically confirmed EMZBL were treated with combination of cyclophosphamide, vincristine, and prednisolone (CVP). Radiotherapy was given to CVP failure cases.

Results: CVP alone resulted in overall response rate of 100% [complete remission (CR), 76.2%]. After a median follow-up of 58 months, 14 (66.7%) of 21 cases were disease free with CVP alone, while seven cases showed disease progression, including two extra-orbital and five local failures. Radiotherapy was delivered to five local failure cases, who subsequently achieved CR with late ophthalmologic complications. There were tolerable adverse events associated with CVP.

Conclusions: Front-line CVP, in conjunction with radiotherapy in recurrent cases, is effective and well tolerated in patients with localized ocular adnexal EMZBL.

chemotherapy, MALT lymphoma, ocular adnexal lymphoma

Received for publication July 4, 2007. Revision received August 16, 2007. Accepted for publication August 20, 2007.


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