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Annals of Oncology Advance Access published online on October 8, 2007
Annals of Oncology, doi:10.1093/annonc/mdm344
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© 2007 European Society for Medical Oncology

Twist expression in patients with cervical cancer is associated with poor disease outcome

K. Shibata*, H. Kajiyama, K. Ino, M. Terauchi, E. Yamamoto, A. Nawa, S. Nomura and F. Kikkawa

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan

* Correspondence to: Dr K. Shibata, Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8550, Japan. Tel: +81-52-744-2263; fax: +81-52-744-2268; E-mail: shiba{at}med.nagoya-u.ac.jp

Background: Twist, a basic helix–-loop–helix transcription factor, has been reported to be associated with the development and progression of human cancer. We examined the distribution and expression of Twist in cervical cancer to examine its clinical significance.

Patients and methods: We examined the distribution and expression of Twist in 101 cervical cancer specimens and determined the association between their expression and the clinico-pathological features observed, including patient outcome.

Results: Of the 101 specimens, 55 cases were negative for Twist immuno-expression, whereas 46 were positive. When categorized into negative versus positive expression, Twist was not associated with any of the clinico-pathological parameters examined. Positive Twist expression significantly predicted poorer overall survival (OS) and progression-free survival (PFS) when compared with negative expression (P < 0.01). In the multivariate analyses, positive Twist expression was an independent prognostic factor for OS (P < 0.05).

Conclusions: Our data imply that positive Twist expression seems to be a useful marker in patients with cervical cancer likely to have an unfavorable clinical outcome.

cervical cancer, epithelial mesenchymal transition (EMT), prognosis, Twist

Received for publication March 6, 2007. Revision received May 17, 2007. Accepted for publication June 4, 2007.


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