Annals of Oncology Advance Access published online on September 4, 2007
Annals of Oncology, doi:10.1093/annonc/mdm338
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© 2007 European Society for Medical Oncology
The role of serum uric acid as an antioxidant protecting against cancer: prospective study in more than 28 000 older Austrian women
1 Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Austria
2 Institute of Epidemiology, Ulm University, Germany
3 Department of General Internal Medicine, Section Oncology, Innsbruck Medical University
4 Cancer Registry of Tyrol, Department of Clinical Epidemiology of the Tyrolean State Hospitals Ltd
5 Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck
6 Agency for Preventive and Social Medicine, Bregenz, Austria
* Correspondence to: Alexander M. Strasak, Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schoepfstrasse 41, A-6020 Innsbruck, Austria. Tel: +43 (512) 9003 70921; Fax: +43 (512) 9003 73922; E-mail: alexander.strasak{at}i-med.ac.at
Background: It has been hypothesized that serum uric acid (SUA), via its antioxidant properties may protect against carcinogenesis. However, few epidemiological investigations have addressed this association and previous findings are inconsistent.
Patients and methods: We prospectively investigated the relation of SUA levels to subsequent cancer mortality in a large cohort of 28613 elderly Austrian women with a median follow-up of 15.2 years. Adjusted Cox proportional hazards models were calculated to evaluate SUA as an independently related factor to fatal cancer events.
Results: High SUA (>5.41 mg/dL) was independently associated with increased risk of total cancer mortality (p<0.0001); the adjusted hazard ratio for the highest versus lowest quartile of SUA was 1.27 (1.08–1.48). SUA levels were further positively related to deaths from malignant neoplasms of breast and female genital organs (P = 0.02) and nervous system and unspecified sites (P = 0.02). We found no evidence for an inverse relationship between SUA levels and risk of total or site-specific cancer mortality.
Conclusion: Our results are contrary to the proposed antioxidant and protective effect of SUA against cancer and rather suggest high SUA concentrations to be associated with outcome possibly reflecting more serious prognostic indication.
antioxidant, cancer mortality, carcinogenesis, epidemiology, older women, risk factor, serum uric acid
Received for publication April 12, 2007. Revision received April 18, 2007. Revision received May 10, 2007. Accepted for publication May 25, 2007.
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