Skip Navigation



Annals of Oncology Advance Access published online on August 20, 2007
Annals of Oncology, doi:10.1093/annonc/mdm334
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
18/11/1799    most recent
mdm334v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Delpech, Y
Right arrow Articles by Barranger, E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Delpech, Y
Right arrow Articles by Barranger, E
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 European Society for Medical Oncology

The sentinel node concept in endometrial cancer: histopathologic validation by serial section and immunohistochemistry

Y Delpech1, A Cortez2, C Coutant1, P Callard2, S Uzan1, E Darai1 and E Barranger1,3,*

1 Department of Gynecologic and Breast Cancers
2 Department of Pathology, Hôpital Tenon
3 Department of Gynecologic-Obstetrics, Hôpital Lariboisiere, Assistance Publique des Hôpitaux de Paris, Paris, France

* Correspondence to: Emmanuel Barranger, MD, Department of Gynecologic-Obstetrics, Hôpital Lariboisiere, 2 rue Ambroise-Pare, 75010 Paris, France. Tel: + 33-1-49-95-84-09; Fax: (33) 1 49 95 84 09; E-mail: emmanuel.barranger{at}lrb.aphp.fr

Background: The sentinel node (SN) is defined as the first node in the lymphatic system that drains a tumor site. If the SN is not metastatic, then all other nodes should also be disease-free. We used serial sections and immunohistochemical (IHC) staining to examine both SN and non-sentinel nodes (non-SNs).

Patients and methods: Twenty-three patients (median age 69 years) with early endometrial cancer underwent a laparoscopic SN procedure based on a combined detection method, followed by complete laparoscopic pelvic lymphadenectomy. If the SN was free of metastasis by both hematoxylin and eosin (H&E) and IHC staining, all non-SNs were also examined by the combined staining method.

Results: SNs were identified in 19 patients (82.6%). A total of 47 SNs were removed (mean 2.5). Ten SNs (21.3%) from five patients (26.3%) were found to be metastatic at the final histologic assessment. In 14 patients, no metastatic SN involvement was detected by H&E and IHC staining. In these 14 patients, 120 non-SNs were examined by serial sectioning and IHC, and none were found to be metastatic.

Conclusion: The SN procedure appears to reliably predict the metastatic status of the regional lymphatic basin in patients with early endometrial cancer.

endometrial cancer, immunohistochemistry, micrometastasis, pathologic staging, patent blue, radiocolloid, sentinel node

Received for publication January 30, 2007. Revision received May 21, 2007. Accepted for publication May 22, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.