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Annals of Oncology Advance Access first published online on April 29, 2007
This version published online on May 7, 2007
Annals of Oncology, doi:10.1093/annonc/mdm136
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© 2007 European Society for Medical Oncology

Docetaxel and oxaliplatin in the second-line treatment of platinum-sensitive recurrent ovarian cancer: a phase II study

G Ferrandina1,2,*, M Ludovisi1, R De Vincenzo1, V Salutari1, D Lorusso2, M Colangelo3, T Prantera4, MR Valerio5 and G Scambia2

1 Gynecologic Oncology Unit, Catholic University of Rome, Rome
2 Department of Oncology, Catholic University of Campobasso, Campobasso
3 Medical Oncology, SS. Annunziata Hospital, Sulmona
4 Medical Oncology, San Giovanni di Dio Hospital, Crotone
5 Department of Oncology, University of Palermo, Palermo, Italy

* Correspondence to: Dr G. Ferrandina, Gynecologic Oncology Unit, Catholic University, L.go A. Gemelli, 8 00168, Rome. Tel/Fax: +39-06-3550-8736; E-mail: gabriella.ferrandina{at}libero.it

Background: A prospective phase II study was conducted to evaluate the efficacy and toxicity of the combination docetaxel (Taxotere) (DTX) and oxaliplatin (OXA) in ovarian cancer patients recurring after a platinum-free interval (PFI) >12 months.

Patients and methods: DTX, 75 mg/m2, was administered by 60 min i.v. infusion, followed by OXA, 100 mg/m2, given by a 2 h i.v., on day 1 every 21 days.

Results: From October 2003 to June 2006, 43 ovarian cancer patients were enrolled. Median PFI was 26 months. All patients were available for response evaluation: 17 complete responses and 12 partial responses were registered, for an overall response rate of 67.4%. The median response duration was 10 months. Stable disease was documented in 11 patients (median duration = 5.5 months). The median time to progression and overall survival were 14 and 28 months. A total of 259 courses were administered. Grade 3–4 leukopenia was documented in 32.5% of the patients, while no case of severe anemia and thrombocytopenia was observed. Grade 3–4 neurotoxicity and grade 2 alopecia were observed in 9.3% and 34.9% of cases, respectively.

Conclusion: DTX/OXA combination is an active regimen with a favorable toxicity profile, for treatment of recurrent platinum-sensitive ovarian cancer patients.

docetaxel, ovarian cancer recurrence, oxaliplatin

Received for publication January 2, 2007. Revision received March 4, 2007. Revision received March 19, 2007. Accepted for publication March 22, 2007.


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