Skip Navigation



Annals of Oncology Advance Access published online on March 7, 2007
Annals of Oncology, doi:10.1093/annonc/mdm066
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
18/10/1595    most recent
mdm066v2
mdm066v1
Right arrow E-letters: Submit a response
Right arrow E-letters: View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kong, A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kong, A
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 European Society for Medical Oncology

review

Adjuvant radiotherapy for stage I endometrial cancer: systematic review and meta-analysis

A Kong1,*, I Simera2, M Collingwood3, C Williams4, H Kitchener5 On behalf of Cochrane Gynaecological Cancer Group

1 Radiotherapy Department, St Bartholomew's Hospital, London EC1
2 Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Linton Road, Oxford OX2 6UD
3 Radiotherapy Department, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ
4 Bristol Haematology and Oncology Centre, Horfield Road, Bristol BS2 8ED
5 Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary's Hospital, Whitworth Park, Manchester M13 0JH, UK

* Correspondence to: Dr A. Kong, Cancer Research UK London Research Institute, 4 Lincoln's Inn Fields, London WC2A 3PX. Tel: +44-207-269-3054; Fax: +44-207-269-3094; E-mail: anthonyhkong{at}hotmail.com

The role of adjuvant radiotherapy in stage I endometrial cancer following surgery remains unclear. The management for these patients varies widely, particularly in stage I patients with different risk factors. Using the methodology of Cochrane Collaboration, we did a systematic and meta-analysis of all know randomised controlled trials which compared adjuvant radiotherapy versus no radiotherapy following surgery for patients with stage I endometrial cancer. The meta-analysis was carried out on four trials (three published and one unpublished) and a total of 1770 patients. The addition of pelvic external beam radiotherapy to surgery reduced locoregional recurrence, a relative risk (RR) of 0.28 [95% confidence interval (CI) 0.17–0.44, P < 0.00001], which is a 72% reduction in the risk of pelvic relapse (95% CI 56% to 83%) and an absolute risk reduction of 6% (95% CI of 4% to 8%). The reduction in the risk of locoregional recurrence did not translate into a reduction in the risks of death from all causes, endometrial cancer death or distant recurrence. A subgroup analysis showed a trend towards the reduction in the risks of death from all causes and endometrial cancer in patients with multiple high risk factors (including stage 1c and grade 3). External beam pelvic radiotherapy should be considered in patients with multiple high-risk features including stage 1c and grade 3. However, it carries an inherent risk of damage and toxicity and should be avoided in stage 1 endometrial cancer patients with no high risk factors.

stage I endometrial carcinoma, adjuvant radiotherapy, systematic review and meta-analysis, death from all causes, locoregional recurrence, endometrial cancer-related deaths

Received for publication January 23, 2007. Accepted for publication January 26, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


E-letters:

Read all E-letters

To the Editor
Sukran Ulger, et al.
Annals of Oncology, 11 Apr 2007 [Full text]

Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.