Skip Navigation



Annals of Oncology Advance Access published online on February 13, 2007
Annals of Oncology, doi:10.1093/annonc/mdl488
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
18/4/694    most recent
mdl488v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wilking, N
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilking, N
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 European Society for Medical Oncology

Long-term follow-up of the SBG 9401 study comparing tailored FEC-based therapy versus marrow-supported high-dose therapy

N Wilking1, E Lidbrink2, T Wiklund3, B Erikstein4, H Lindman5, P Malmström6, P Kellokumpu-Lehtinen7, N-O Bengtsson8, G Söderlund9, G Anker10, E Wist11, S Ottosson12, E Salminen13, P Ljungman14, H Holte15, J Nilsson16, C Blomqvist17, J Bergh On behalf of the Scandinavian Breast Group, study SBG 94011,2,*,{dagger}

1 Department of Oncology, Karolinska Institutet, Stockholm, Sweden
2 Radiumhemmet, Karolinska Institutet and University Hospital, Stockholm
3 Roche OY, Espoo, Finland
4 Southern Norway Regional Health Authority, Skien, Norway
5 Department of Oncology, Akademiska Hospital, Uppsala, Sweden
6 Department of Oncology, University Hospital, Lund, Sweden
7 Department of Oncology, Tampere University and University Hospital, Finland
8 Department of Oncology, University Hospital, Umeå, Sweden
9 Department of Oncology, University Hospital, Linköping, Sweden
10 Department of Oncology, Haukeland University Hospital, Bergen, Norway
11 Department of Oncology, Ullevål University Hospital and Faculty of Medicine, University of Oslo, Norway
12 Department of Oncology, NÄL, Trollhttan, Sweden
13 Department of Oncology, Turku University Hospital, Finland
14 Haematology Centre, Karolinska University Hospital, Stockholm, Sweden
15 Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
16 Trial Form Support AB, Stockholm, Sweden
17 Department of Oncology, University Hospital, Helsinki, Finland

* Correspondence to: Dr J. Bergh, Department of Oncology, Radiumhemmet, Karolinska Institutet and University Hospital, Solna, S-171 76 Stockholm, Sweden. Tel: +46-70-484-85-02; Fax: +46-85-177-95-24; E-mail: jonas.bergh{at}ki.se

Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm.

Patients and methods: Five hundred and twenty-five women below the age of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorouracil, epirubicin, cyclophosphamide), (n = 251) or standard FEC followed by marrow-supported high-dose therapy with CTCb (cyclophosphamide, thiotepa, carboplatin) therapy (n = 274), followed by locoregional radiotherapy and tamoxifen for 5 years.

Results: There were 104 breast cancer relapses in the tailored FEC group versus 139 in the CTCb group (double triangular method by Whitehead, P = 0.046), with a median follow-up of all included patients of 60.8 months. The event-free survival demonstrated 121 and 150 events in the tailored FEC- and CTCb group, respectively [P = 0.074, hazard ratio (HR) 0.804, 95% confidence interval (CI) 0.633–1.022]. Ten patients in the tailored FEC regimen developed acute myeloid leukaemia (AML)/myelodysplasia (MDS). One hundred deaths occurred in the tailored FEC group and 121 in the CTCb group (P = 0.287, HR 0.866, 95% CI 0.665–1.129).

Conclusion: The update of this study shows an improved outcome linked to the tailored FEC treatment in relation to breast cancer relapse, but also an increased incidence of AML/MDS.

adjuvant, breast cancer, randomised, tailored chemotherapy

{dagger} Participants in the SBG 9401 study group are listed in the Appendix.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.