Annals of Oncology Advance Access published online on October 17, 2006
Annals of Oncology, doi:10.1093/annonc/mdl352
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1 Istituto Toscano Tumori, Environmental and Occupational Epidemiology Unit, Centre for Study and Prevention of Cancer, Florence
* To whom correspondence should be addressed. Background: Few studies have analysed the association between alcohol intake and Hodgkin's lymphoma (HL) or multiple myeloma (MM) risks. Materials and methods: A multicentre population-based case-control study of 363 HL, 270 MM cases, and 1771 controls offered the opportunity to evaluate the relationship between alcohol and HL/MM risks. Unconditional logistic regression was carried out to estimate odds ratios (ORs) and 95% confidence intervals (CIs), associated with alcohol intake (servings per week, grams per day of ethanol intake) or duration of exposure (year). Results: For HL, considering nonsmokers only, ever drinkers had a significantly decreased risk than never drinkers (OR = 0.46). Significantly lower risks in all levels of total alcohol intake were also detected, considering servings per week (OR for one to four servings per week = 0.51, 95% CI 0.32-0.82; OR for five to nine servings per week = 0.39, 95% CI 0.21-0.73; OR for 10-19 servings per week = 0.26, 95% CI 0.12-0.54; OR for Conclusions: Our study indicates a protective effect of alcohol consumption for nonsmoking HL cases.
Received May 5, 2006
Revised July 28, 2006
Accepted August 8, 2006
original article
Alcohol consumption and risk of Hodgkin's lymphoma and multiple myeloma: a multicentre case-control study
G. Gorini 1 *, E. Stagnaro 2, V. Fontana 2, L. Miligi 1, V. Ramazzotti 3, D. Amadori 4, S. Rodella 5, R. Tumino 6, P. Crosignani 7, C. Vindigni 8, A. Fontana 9, P. Vineis 10, and A. Seniori Costantini 1
2 Epidemiology and Biostatistics Unit, National Cancer Research Institute, Genoa
3 National Cancer Institute Regina Elena, Rome
4 Oncology Department, Azienda USL Forlì, Forlì
5 Azienda Ospedaliera, Verona
6 Cancer registry & Pathology Unit, Azienda Ospedaliera "Civile M.P. Arezzo," Ragusa
7 Epidemiology Unit, National Cancer Institute, Milan
8 Pathology Institute, University of Siena, Siena
9 Local Health Unit, Novara
10 Cancer Epidemiology Unit, University of Turin, Italy; Imperial College--London, UK
G. Gorini, E-mail: g.gorini{at}cspo.it
Abstract 
20 servings per week = 0.34, 95% CI 0.15-0.79) and grams per day of ethanol intake (OR for 0.1-9.0 g/day = 0.45, 95% CI 0.27-0.74; OR for 9.1-17.9 g/day = 0.52, 95% CI 0.30-0.90; OR for 18.0-31.7 g/day = 0.27, 95% CI 0.13-0.57; OR for >31.7 g/day = 0.35, 95% CI 0.15-0.79). In the analysis for ever-smoking HL cases and controls, ever drinkers had the same risk as never drinkers. For MM, ever drinkers had a non-significantly decreased risk than non-drinkers (OR = 0.74), and ORs in almost all consumption levels were not significant (OR for 0.1-9.0 g/day = 0.93; OR for 9.1-17.9 g/day = 0.82; OR for 18.0-31.7 g/day = 0.47; 95% CI 0.28-0.81; OR for >31.7 g/day = 0.68). For HL and MM, the beverage type did not affect the risk significantly, and no consistent dose-response relationships were found, considering intensity or duration of alcohol consumption.
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  S Deandrea, P Bertuccio, L Chatenoud, S Franceschi, D Serraino, and C La Vecchia Reply to 'Alcohol consumption and risk of Hodgkin's lymphoma and multiple myeloma: a multicentre case-control study' by Gorini et al. Ann. Onc., June 1, 2007; 18(6): 1119 - 1121. [Full Text] [PDF]
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