Skip Navigation



Annals of Oncology Advance Access published online on October 9, 2006
Annals of Oncology, doi:10.1093/annonc/mdl332
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
18/5/817    most recent
mdl332v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Blijlevens, N.
Right arrow Articles by Sonis, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blijlevens, N.
Right arrow Articles by Sonis, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2006 European Society for Medical Oncology
Received February 1, 2006
Revised July 17, 2006
Accepted August 14, 2006

review

Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis

N. Blijlevens 1 * and S. Sonis 2

1 Department of Haematology, University Medical Centre, St Radboud, Nijmegen, The Netherlands
2 Division of Oral Medicine, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA

* To whom correspondence should be addressed.
N. Blijlevens, E-mail: Blijlevens{at}HEMAT.umcn.nl


  Abstract

Oral and intestinal mucositis are among the most significant dose-limiting toxic effects of intensive cancer treatment and are associated with adverse clinical and economic outcomes. Palifermin (KepivanceTM), an N-truncated recombinant human keratinocyte growth factor-1, is the first agent to be approved for prevention of oral mucositis. Keratinocyte growth factor, a potent epithelial mitogen, appears to play a major role in the healing process. Palifermin has multiple biological activities that appear to protect the mucosal epithelium and promote its early regeneration after irradiation- and chemotherapy-induced injury. These include inhibition of epithelial cell apoptosis and DNA damage, up-regulation of detoxifying enzymes and down-regulation of pro-inflammatory cytokines, as well as enhanced migration, proliferation and differentiation of epithelial cells. Palifermin reduces the incidence, severity and duration of oral mucositis in patients with haematological malignancies undergoing myelotoxic conditioning therapy and haematopoietic stem-cell transplantation. Clinical sequelae, including febrile neutropenia and resource use (opioid analgesia and parenteral feeding), are concomitantly reduced. Other potential applications being explored include use in the solid tumour setting, reduction of intestinal mucositis and reduction of GVHD in allogenic transplantation. Thus, the development of palifermin and other potential new agents for preventing chemotherapy- and radiotherapy-induced mucositis represents an important breakthrough in oncological supportive care.

Keywords: anti-neoplastic agents; adverse effects; growth factors; haematopoietic stem-cell transplantation; keratinocyte growth factor; mucositis; palifermin.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann OncolHome page
E. Schmidt, N. H. Thoennissen, A. Rudat, R. Bieker, C. Schliemann, R. M. Mesters, M. Zuhlsdorf, C. Muller-Tidow, and W. E. Berdel
Use of palifermin for the prevention of high-dose methotrexate-induced oral mucositis
Ann. Onc., September 1, 2008; 19(9): 1644 - 1649.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
J. P. M. Derikx, N. M. A. Blijlevens, J. P. Donnelly, H. Fujii, T. Kanda, A. A. van Bijnen, E. Heineman, and W. A. Buurman
Loss of enterocyte mass is accompanied by diminished turnover of enterocytes after myeloablative therapy in haematopoietic stem-cell transplant recipients
Ann. Onc., August 25, 2008; (2008) mdn579v1.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
N. Blijlevens, M. Schwenkglenks, P. Bacon, A. D'Addio, H. Einsele, J. Maertens, D. Niederwieser, W. Rabitsch, A. Roosaar, T. Ruutu, et al.
Prospective Oral Mucositis Audit: Oral Mucositis in Patients Receiving High-Dose Melphalan or BEAM Conditioning Chemotherapy--European Blood and Marrow Transplantation Mucositis Advisory Group
J. Clin. Oncol., March 20, 2008; 26(9): 1519 - 1525.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Zhang, E. Hexner, D. Frank, and S. G. Emerson
CD4+ T Cells Generated De Novo from Donor Hemopoietic Stem Cells Mediate the Evolution from Acute to Chronic Graft-versus-Host Disease
J. Immunol., September 1, 2007; 179(5): 3305 - 3314.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. S.J. Yeoh, R. J. Gibson, E. E.K. Yeoh, J. M. Bowen, A. M. Stringer, K. A. Giam, and D. M.K. Keefe
A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-{kappa}B, COX-1, and COX-2
Mol. Cancer Ther., August 1, 2007; 6(8): 2319 - 2327.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.