Annals of Oncology Advance Access published online on October 3, 2006
Annals of Oncology, doi:10.1093/annonc/mdl329
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Divisions of Hematology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
* To whom correspondence should be addressed. Background: Primary bone lymphoma (PBL) is a distinct clinicopathological entity. Although PBL has been reviewed in several small studies, few reflect recent improvements in primary treatment. Methods: We used the British Columbia Cancer Agency Lymphoid Cancer Database to identify all patients with PBL (1983-2005). All were staged in a uniform manner and treated with era-specific protocols. Results: We identified 131 patients with a median age of 63 years (18-87). One third had disease in long bones and another one third had disease in the spine, of which half presented with spinal cord compression. Patients with diffuse large-cell lymphoma (DLCL) (n = 103, 79%) had 5- and 10-year overall survivals (OS) of 62% and 41%, respectively. Multivariate analysis identified three prognostic groups: age <60 with International Prognostic Index (IPI) 1-3 (n = 43), age Conclusions: PBL is usually of DLCL type and has an improved outcome with CHOPR. Younger patients with good IPI score have a favorable prognosis.
Received May 31, 2006
Revised August 10, 2006
Accepted August 11, 2006
original article
A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency
K. M. Ramadan 1, T. Shenkier 2, L. H. Sehn 2, R. D. Gascoyne 3, and J. M. Connors 2 *
2 Divisions of Medical Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
3 Divisions of Pathology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
J. M. Connors, E-mail: jconnors{at}bccancer.bc.ca
Abstract 
60 with IPI 0-3 (n = 23) and age 60 with IPI 4-5 (n = 33), with markedly different 5-year OS of 90%, 61% and 25%, respectively (P < 0.0001). Neither primary site nor pathological fracture at presentation had an impact on OS. The 3-year progression-free survival in patients who received rituximab plus combination chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOPR) chemotherapy was 88% compared with 52% in those who received CHOP-like chemotherapy without rituximab (P = 0.005). The 10-year OS for those with advanced-stage disease who received irradiation plus chemotherapy was 25% versus 56% for those who received chemotherapy alone (P = 0.025). Patients received irradiation if spinal cord compression was present or residual disease at the end of chemotherapy was thought to require it.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  F H Heyning, P C W Hogendoorn, M H H Kramer, C T Q Holland, E Dreef, and P M Jansen Primary lymphoma of bone: extranodal lymphoma with favourable survival independent of germinal centre, post-germinal centre or indeterminate phenotype J. Clin. Pathol., September 1, 2009; 62(9): 820 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-S. Chim, C. P. Bik Yiu, and W. H. Shek Pathological Bone Fracture in Non-Hodgkin's Lymphoma J. Clin. Oncol., July 20, 2007; 25(21): 3175 - 3176. [Full Text] [PDF]
|
|