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Annals of Oncology Advance Access published online on October 3, 2006
Annals of Oncology, doi:10.1093/annonc/mdl328
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© 2006 European Society for Medical Oncology
Received May 9, 2006
Revised July 24, 2006
Accepted August 8, 2006

original article

Fried foods, olive oil and colorectal cancer

C. Galeone 1 *, R. Talamini 2, F. Levi 3, C. Pelucchi 1, E. Negri 1, A. Giacosa 4, M. Montella 5, S. Franceschi 6, and C. La Vecchia 7

1 Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan
2 Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
3 Unité d'épidémiologie du cancer, Institut universitarie de médicine sociale et préventive, Lausanne, Switzerland
4 Policlinico di Monza, Via Amati, Monza, Milan
5 Servizio di Epidemiologia, Istituto Tumori ‘Fondazione Pascale’, Naples, Italy
6 International Agency for Research on Cancer, Lyon, France
7 Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan; Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Italy

* To whom correspondence should be addressed.
C. Galeone, E-mail: galeone{at}marionegri.it


  Abstract

Background: The epidemiologic evidence for an etiologic role of fried foods and heterocyclic amines in colorectal carcinogenesis is inconsistent.

Patients and methods: We have investigated the relation between fried foods and colorectal cancer risk using data from a large, multicentric case-control study conducted in Italy and Switzerland between 1992 and 2000, with 1394 cases of colon cancer, 886 cases of rectal cancer and 4765 controls.

Results: After allowing for major relevant covariates, the multivariate odds ratios (ORs) for an increment of one portion per week of fried foods were 0.97 [95% confidence interval (CI) = 0.93-1.01] for colon cancer and 1.04 (95% CI = 1.00-1.09) for rectal cancer. When we analyzed the type of fats mainly used for frying, we found that olive oil, but not other types of oils, appeared to protect from colon cancer risk (OR = 0.89, 95% CI = 0.82-0.98).

Conclusions: Our results do not indicate a relevant role of fried foods on colorectal cancer risk. We found a possible favorable effect of (fried) olive oil on colon cancer risk but not on rectal cancer risk.

Keywords: acrylamide; case-control study; colorectal cancer; fried foods; heterocyclic amines; olive oil.
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