Annals of Oncology Advance Access published online on February 23, 2006
Annals of Oncology, doi:10.1093/annonc/mdl014
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1 Department of Internal Medicine I, Medical University Vienna, Austria
* To whom correspondence should be addressed. Background: 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) has become a routine measure for staging and follow-up of patients with aggressive lymphoma. By contrast, its usefulness to visualize indolent lymphomas characterized by a lower cellular turnover has not clearly been defined. We have investigated accuracy and clinical usefulness of 18F-FDG-PET in patients with follicular lymphoma (FL). Patients and methods: A total of 64 patients with FL WHO grade I - III (48, 5, and 11 patients) were imaged at our institution to assess the value of 18F-FDG-PET for imaging of FL of different gradings. A total of 115 scans (48 before therapy and 67 for response assessment after treatment) were performed, and findings were compared to conventional staging including CT-scan of thorax and abdomen, sonography of lymph nodes and bone marrow biopsy. Results: Overall, 18F-FDG-PET had a sensitivity of 98%, a specificity of 94%, a positive predictive value of 95% and a negative predictive value of 98%. These results were significantly more accurate (P = 0.023) than the conventional radiology studies. There was no significant difference (P = 0.093) in the accuracy between patients with indolent (WHO grade I and II) versus aggressive FL (WHO grade III). Conclusion: 18F-FDG-PET scan is a reliable method for staging and follow up of patients with nodal FL irrespective of tumor grading.
Received January 5, 2006
Accepted January 10, 2006
original article
18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) visualizes follicular lymphoma irrespective of grading
S. Wöhrer 1,
U. Jaeger 1,
K. Kletter 2,
A. Becherer 2,
A. Hauswirth 1,
K. Turetschek 3,
M. Raderer 1,
and
M. Hoffmann 2 *
2 Department of Nuclear Medicine and Medical University Vienna, Austria
3 Department of Radiology, Medical University Vienna, Austria
M. Hoffmann, E-mail: martha.hoffmann{at}meduniwien.ac.at
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