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Annals of Oncology Advance Access published online on February 23, 2006
Annals of Oncology, doi:10.1093/annonc/mdl008
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© 2006 European Society for Medical Oncology
Received October 28, 2005
Revised December 30, 2005
Accepted January 3, 2006

review

Neo-adjuvant chemotherapy for muscle-invasive bladder cancer: a look ahead

R. Sawhney 1, D. Bourgeois 2, and U. B. Chaudhary 1 *

1 Department of Medicine, Division of Hematology/Oncology, South Carolina, USA
2 Department of Pathology, Medical University of South Carolina, South Carolina, USA

* To whom correspondence should be addressed.
U. B. Chaudhary, E-mail: chaudu{at}musc.edu


  Abstract

Randomized clinical trials of neo-adjuvant cisplatin-based combination chemotherapy for locally advanced muscle invasive bladder cancer has shown a survival benefit over cystectomy alone. Pathologic complete response (pT0) after neo-adjuvant chemotherapy is emerging as a potentially important surrogate clinical end point. Future clinical trials incorporating targeted therapies with novel clinical end points may accelerate development of therapeutic strategies for locally advanced muscle invasive bladder cancer. Furthermore, evaluation of molecular markers may further help to stratify patients to a risk adapted approach.

Keywords: bladder cancer; chemotherapy; neoadjuvant; pT0.
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