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Annals of Oncology Advance Access published online on March 8, 2006
Annals of Oncology, doi:10.1093/annonc/mdj120
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© 2006 European Society for Medical Oncology
Received July 28, 2005
Revised November 15, 2005
Accepted November 29, 2005

original article

The clinical significance of ZAP-70 and CD38 expression in B-cell chronic lymphocytic leukaemia

I. Hus 1 *, M. Podhorecka 1, A. Bojarska-Junak 2, J. Rolinski 2, M. Schmitt 3, M. Sieklucka 2, E. Wasik-Szczepanek 1, and A. Dmoszynska 1

1 Department of Haemato-oncology, Medical University of Lublin, Poland
2 Department of Clinical Immunology, Medical University of Lublin, Poland
3 3rd Department of Internal Medicine, University of Ulm, Germany

* To whom correspondence should be addressed.
I. Hus, E-mail: iwohus{at}wp.pl


  Abstract

Background: B-cell chronic lymphocytic leukaemia (B-CLL) is a disease with a highly variable clinical course; some patients never need treatment, while others require intensive treatment early after diagnosis. Recently, some new prognostic factors, such as IgVH mutational status, ZAP-70 and the expression of CD38 in leukaemic cells were introduced to identify attenuated versus progressive types of CLL bearing the potential to facilitate risk-adapted treatment strategies.

Patients and methods: To evaluate the clinical value of ZAP-70 and CD38 as predictors of disease progression we assessed the expression of these markers by the flow cytometry method in 156 B-CLL patients.

Results and conclusions: Both ZAP-70 and CD38 expression were shown to predict the clinical course of the disease, while ZAP-70 expression appeared to be more predictive than CD38 expression and more relevant in defining the cases of B-CLL responsive or refractory to first line chemotherapy. A simultaneous evaluation of ZAP-70 and CD38 expression allowed distinguishing the patients groups with the most favourable prognosis as well as those with the worst. Taken together we recommend assessing both ZAP-70 and CD38 protein expression for the definition of prognostic subgroups in patients with B-CLL

Keywords: B-cell chronic lymphocytic leukaemia; ZAP-70; CD38.
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