Skip Navigation



Annals of Oncology Advance Access published online on November 10, 2005
Annals of Oncology, doi:10.1093/annonc/mdj031
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
17/1/50    most recent
mdj031v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Glynne-Jones, R.
Right arrow Articles by McDonald, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Glynne-Jones, R.
Right arrow Articles by McDonald, A. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 European Society for Medical Oncology
Received May 27, 2005
Revised September 1, 2005
Accepted September 2, 2005

original article

A phase I dose escalation study of continuous oral capecitabine in combination with oxaliplatin and pelvic radiation (XELOX-RT) in patients with locally advanced rectal cancer

R. Glynne-Jones 1*, D. Sebag-Montefiore 2, T. S. Maughan 3, S. J. Falk 4, and A. C. McDonald 5

1 Mount Vernon Cancer Centre, Northwood, London, UK
2 Leeds Cancer Centre, Leeds, UK
3 Velindre Cancer Centre, Whitchurch, UK
4 The Bristol Haematology & Oncology Centre, Bristol, UK
5 Beatson Oncology Centre, Glasgow, UK

* To whom correspondence should be addressed.
R. Glynne-Jones, E-mail: rob.glynne-jones{at}whht.nhs.uk


  Abstract

Purpose: To determine the maximum tolerated dose (MTD) of continuous oral capecitabine plus oxaliplatin and pre-operative pelvic radiotherapy (XELOX-RT).

Patients and methods: Patients with clinically unresectable rectal cancer or for whom resection with histologically clear (R0) surgical margins was unlikely received continuous capecitabine (500-825 mg/m2 twice daily, 7 days/week), oxaliplatin 2-h intravenous infusion (130 mg/m2 days 1 and 29) and pelvic radiotherapy (Monday-Friday for 5 weeks, total dose 45 Gy in 25 daily 1.8 Gy fractions). The MTD was the capecitabine dose causing dose-limiting toxicities (DLTs; treatment-related grade 3/4 toxicities) in one-third or more of patients treated per dose level.

Results: Eighteen patients received three dose levels. The MTD was capecitabine 825 mg/m2 twice daily: DLTs occurred in two of six patients (grade 3 diarrhoea, rectal pain with local skin reaction). No DLTs occurred in six patients receiving capecitabine 650 mg/m2 twice daily. Grade 3/4 toxicity was rare, with minimal myelosuppression. Although predominantly a dose-finding study, XELOX-RT showed promising activity. Fourteen patients had histologically confirmed R0 resections and five had a pathological complete response.

Conclusions: The recommended dose for further study is capecitabine 650 mg/m2 twice daily with oxaliplatin and radiotherapy. XELOX-RT showed promising antitumour activity. Further evaluation is underway.

Keywords: Capecitabine; chemoradiation; locally advanced rectal cancer; oxaliplatin.

R. Glynne-Jones and D. Sebag-Montefiore contributed equally to this work.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann. Surg. Oncol.Home page
G. A. Hospers, C. J. A. Punt, M. E. Tesselaar, A. Cats, K. Havenga, J. W. H. Leer, C. A. Marijnen, E. P. Jansen, H. H. J. M. Van Krieken, T. Wiggers, et al.
Preoperative Chemoradiotherapy with Capecitabine and Oxaliplatin in Locally Advanced Rectal Cancer. A Phase I II Multicenter Study of the Dutch Colorectal Cancer Group
Ann. Surg. Oncol., October 1, 2007; 14(10): 2773 - 2779.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. Rodel, T. Liersch, R. M. Hermann, D. Arnold, T. Reese, M. Hipp, A. Furst, N. Schwella, M. Bieker, G. Hellmich, et al.
Multicenter Phase II Trial of Chemoradiation With Oxaliplatin for Rectal Cancer
J. Clin. Oncol., January 1, 2007; 25(1): 110 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
F. A. Calvo, F. J. Serrano, J. A. Diaz-Gonzalez, M. Gomez-Espi, E. Lozano, R. Garcia, D. de la Mata, J. A. Arranz, P. Garcia-Alfonso, G. Perez-Manga, et al.
Improved incidence of pT0 downstaged surgical specimens in locally advanced rectal cancer (LARC) treated with induction oxaliplatin plus 5-fluorouracil and preoperative chemoradiation
Ann. Onc., July 1, 2006; 17(7): 1103 - 1110.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
R. Glynne-Jones, J. Dunst, and D. Sebag-Montefiore
The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been?
Ann. Onc., March 1, 2006; 17(3): 361 - 371.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.