Annals of Oncology Advance Access published online on May 26, 2005
Annals of Oncology, doi:10.1093/annonc/mdi267
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1 Division of Hematology-Oncology, Department of Medicine
* To whom correspondence should be addressed. Background: To understand the pathogenesis of fatigue in cancer, we conducted a cross-sectional study using Brief Fatigue Inventory (BFI) and Functional Assessment of Cancer Therapy-Fatigue (FACT-F) instruments to measure fatigue and assessed laboratory studies. Patients and methods: 174 patients with cancer, who had undergone treatment within the last six months, answered the questionnaires and the Brief Version Zung Self-Rating Depression Scale (BZSDS). Blood samples were drawn for hemoglobin, albumin, thyroid stimulating hormone (TSH), dehydroepiandrosterone-sulfate (DHEAS) and tumor necrosis factor-alpha (TNF- alpha). Testosterone levels were checked in male patients. Results: Clinically significant fatigue with BFI Conclusion: Fatigue is common in this population and BFI correlates with more extensive measurements. Abnormalities such as decreased testosterone and DHEAS may lead to interventions that can be therapeutically exploited.
Received February 1, 2005
Revised April 13, 2005
Accepted April 14, 2005
Original article
Screening studies for fatigue and laboratory correlates in cancer patients undergoing treatment
2 Division of Hematology-Oncology, Department of Medicine, Walther Cancer Institute, Indianapolis, IN, USA
3 Division of Biostatistics, Indiana University School of Medicine
L. H. Einhorn, E-mail: leinhorn{at}iupui.edu
Abstract 
4 was present in 52.0% of patients. Measurement of laboratory parameters revealed the following: DHEAS levels <80 mcg/dl in males and <36 mcg/dl in females=54.1%; BZSDS scores 27=20.1%; testosterone levels <200 ng/dl=26.4% of male patients. Significant correlations were noted between BFI and FACT-F, albumin levels, hemoglobin levels and BZSDS scores. In addition, for male patients BFI correlated with DHEAS and testosterone levels. In multiple linear regression, hemoglobin, BZSDS scores and current opioid use were associated with response BFI. For male patients, DHEAS <80 mcg/dl, increased BZSDS and testosterone <200 ng/dl were associated with increased BFI.
Presented in part at the 39th Annual Meeting of the American Society of Clinical Oncology, Chicago, IL, 31 May 31-3 June 2003.
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