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Annals of Oncology Advance Access published online on April 22, 2005
Annals of Oncology, doi:10.1093/annonc/mdi224
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© 2005 European Society for Medical Oncology
Received December 8, 2004
Revised February 19, 2005
Accepted February 21, 2005

Original article

Prognostic significance of syndecan-1 expression in human endometrial cancer

Hasengaowa 1, J. Kodama 1*, T. Kusumoto 1, Y. Shinyo 1, N. Seki 1, and Y. Hiramatsu 1

1 Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

* To whom correspondence should be addressed.
J. Kodama, E-mail: kodama{at}cc.okayama-u.ac.jp


  Abstract

Background: Syndecan-1 binds to various extracellular matrix components via its heparan sulfate glycosaminoglycans. The aim of this study was to investigate syndecan-1 expression in endometrial cancers.

Patients and methods: We investigated the expression of the syndecan-1 core protein by immunohistochemistry in 109 endometrial cancers, and analyzed correlation with various clinicopathological features, including patient outcome.

Results: Epithelial syndecan-1 expression was significantly lower in advanced stage, high grade, deep myometrial invasion, cervical involvement, lymph node metastasis, lymph vascular space involvement and positive peritoneal cytology. Stromal syndecan-1 expression was significantly higher in high-grade tumors. The disease-free and overall survival rates of patients exhibiting both low epithelial and high stromal syndecan-1 expression was poor. Multivariate analysis showed that high stromal syndecan-1 expression was an independent prognostic factor for both disease-free and overall survival. Low epithelial syndecan-1 expression was a prognostic factor only in the univariate analysis.

Conclusions: Loss of epithelial syndecan-1 and induction of stromal syndecan-1 expression may be associated with tumor progression. Stromal syndecan-1 expression can serve as an indicator of poor prognosis in patients with endometrial cancer.

Keywords: endometrial cancer; prognosis; syndecan-1.
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