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Annals of Oncology Advance Access published online on June 6, 2005
Annals of Oncology, doi:10.1093/annonc/mdi208
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© 2005 European Society for Medical Oncology
Received January 13, 2005
Accepted February 2, 2005

Original article

Bevacizumab--current status and future directions

Rachel Midgley 1* and David Kerr 1

1 Department of Clinical Pharmacology and Cancer Therapeutics, Racliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK

* To whom correspondence should be addressed.
Rachel Midgley, E-mail: Rachel.Midgley{at}cancer.org.uk


  Abstract

Angiogenesis is crucial to tumour initiation, survival and metastasis. Vascular endothelial growth factor (VEGF) is one of the most important pro-angiogenic factors in cancer development. Bevacizumab (a humanised monoclonal antibody against VEGF) has a reasonable safety profile and proven efficacy in a phase III trial in advanced colorectal cancer. Efficacy of Bevacizumab also looks promising in non small cell lung cancer, renal cancer and a variety of other solid tumours. Questions still surround optimal dosing and the appropriate selection of patients who are most likely to benefit. Future trials will address these questions and provide further translational insights.

Keywords: angiogenesis; bevacizumab; vascular endothelial growth factor.
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