Annals of Oncology Advance Access published online on March 31, 2005
Annals of Oncology, doi:10.1093/annonc/mdi162
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Academic Unit of Clinical Oncology, Yorkshire Cancer Research Centre, Weston Park Hospital, Sheffield, UK
* To whom correspondence should be addressed. Breast cancer is the leading type of cancer among women, and bone metastases are common in patients with breast cancer, affecting more than half of all patients with advanced disease. Bisphosphonates are the current standard of care for preventing skeletal complications associated with bone metastases. Clinical trials investigating the benefit of bisphosphonate therapy have used a composite end point defined as a skeletal-related event (SRE) or bone event, which typically includes pathologic fracture, spinal cord compression, radiation or surgery to bone, and hypercalcaemia of malignancy. Bisphosphonates significantly reduced the incidence of these events. Zoledronic acid, pamidronate, clodronate and ibandronate have demonstrated efficacy compared with placebo. Zoledronic acid has also been compared with another active bisphosphonate (i.e. pamidronate) and shown by multiple event analysis to be significantly more effective at reducing the risk of SREs. Bisphosphonates effectively reduce and prevent skeletal complications in patients with bone metastases from breast cancer. Preclinical data suggest that bisphosphonates have antitumour effects. Bisphosphonates may also be of use in the adjuvant setting.
Received October 26, 2004
Revised January 4, 2005
Accepted January 7, 2005
Review
Bisphosphonates in breast cancer
R. E. Coleman, E-mail: r.e.coleman{at}sheffield.ac.uk
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. SIMMONS, E. AMIR, G. DRANITSARIS, M. CLEMONS, B. WONG, R. VEITH, and D. E.C. COLE Altered Calcium Metabolism in Patients on Long-term Bisphosphonate Therapy for Metastatic Breast Cancer Anticancer Res, July 1, 2009; 29(7): 2707 - 2711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Van den Wyngaert, M. T. Huizing, E. Fossion, and J. B. Vermorken Bisphosphonates in Oncology: Rising Stars or Fallen Heroes Oncologist, February 1, 2009; 14(2): 181 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J-J Body, M Lichinitser, S Tjulandin, P Garnero, and B Bergstrom Oral ibandronate is as active as intravenous zoledronic acid for reducing bone turnover markers in women with breast cancer and bone metastases Ann. Onc., July 1, 2007; 18(7): 1165 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. G. Russell Bisphosphonates: Mode of Action and Pharmacology Pediatrics, March 1, 2007; 119(Supplement_2): S150 - S162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kroemer, L. Galluzzi, and C. Brenner Mitochondrial Membrane Permeabilization in Cell Death Physiol Rev, January 1, 2007; 87(1): 99 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Chien and P. E. Goss Aromatase Inhibitors and Bone Health in Women With Breast Cancer J. Clin. Oncol., November 20, 2006; 24(33): 5305 - 5312. [Full Text] [PDF]
|
|
|
|
|
|
M. Botteman, V. Barghout, J. Stephens, J. Hay, J. Brandman, and M. Aapro Cost effectiveness of bisphosphonates in the management of breast cancer patients with bone metastases Ann. Onc., July 1, 2006; 17(7): 1072 - 1082. [Abstract] [Full Text] [PDF]
|
|