Skip Navigation



Annals of Oncology Advance Access published online on March 24, 2005
Annals of Oncology, doi:10.1093/annonc/mdi151
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
16/5/756    most recent
mdi151v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Guyot, F.
Right arrow Articles by Bouvier, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guyot, F.
Right arrow Articles by Bouvier, A. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 European Society for Medical Oncology
Received September 1, 2004
Revised December 13, 2004
Accepted December 20, 2004

Original article

Time trends in the treatment and survival of recurrences from colorectal cancer

F. Guyot 1, J. Faivre 1, S. Manfredi 1, B. Meny 1, C. Bonithon-Kopp 1, and A. M. Bouvier 1*

1 Registre Bourguignon des Cancers Digestifs (INSERM EPI 0106 and CIC-EC01), Faculté de Médecine, Dijon Cedex, France

* To whom correspondence should be addressed.
A. M. Bouvier, E-mail: Anne-Marie.Bouvier{at}u-bourgogne.fr


  Abstract

Background: Little is known about the management of recurrences from colorectal cancer at a population level.

Materials and methods: Data was obtained from the population-based cancer registry of Côte d'Or (Burgundy, France) over a 28-year period. Univariate and multivariate analyses were performed to analyse trends in treatment and survival for local recurrence and distant metastases.

Results: The proportion of patients resected for cure increased from 6.7% (1976-1984) to 23.7% (1994-2003; P <0.001) for distant metastases and from 15.9% to 58.1% (P <0.001) for local recurrence. Age and period of diagnosis were independent factors associated with a resection for cure. Rectal cancer local recurrence was less often resected for cure than colon cancer local recurrence (P=0.05). Long-term survival was observed only after resection for cure: 5-year relative survival rates were 36.1% for local recurrence and 24.0% for distant metastases. In the multivariate analysis, survival decreased with age and increased over time but significantly only over the last study period. Surgical resection and palliative chemotherapy were other determinants of prognosis for distant metastases whereas surgical resection and palliative radiotherapy did influence the prognosis for local recurrence.

Conclusion: Substantial advances in the management of recurrences have been achieved over time. More effective treatments and mass screening represent promising approaches to decrease this problem.

Keywords: colorectal cancer; distant metastases; local recurrence; cancer registry; survival; treatment.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann OncolHome page
D. Papamichael, R. Audisio, J.-C. Horiot, B. Glimelius, J. Sastre, E. Mitry, E. Van Cutsem, M. Gosney, C.-H. Kohne, and M. Aapro
Treatment of the elderly colorectal cancer patient: SIOG expert recommendations
Ann. Onc., January 1, 2009; 20(1): 5 - 16.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. E. Desch, A. B. Benson III, M. R. Somerfield, P. J. Flynn, C. Krause, C. L. Loprinzi, B. D. Minsky, D. G. Pfister, K. S. Virgo, N. J. Petrelli, et al.
Colorectal Cancer Surveillance: 2005 Update of an American Society of Clinical Oncology Practice Guideline
J. Clin. Oncol., November 20, 2005; 23(33): 8512 - 8519.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Krajewska, H. Kim, C. Kim, H. Kang, K. Welsh, S.-i. Matsuzawa, M. Tsukamoto, R. G. Thomas, N. Assa-Munt, Z. Piao, et al.
Analysis of Apoptosis Protein Expression in Early-Stage Colorectal Cancer Suggests Opportunities for New Prognostic Biomarkers
Clin. Cancer Res., August 1, 2005; 11(15): 5451 - 5461.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.