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Annals of Oncology Advance Access published online on March 31, 2005
Annals of Oncology, doi:10.1093/annonc/mdi148
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© 2005 European Society for Medical Oncology
Received December 9, 2004
Accepted December 20, 2004

Original article

Report of a European consensus workshop to develop recommendations for the optimal use of 90Y-ibritumomab tiuxetan (Zevalin®) in lymphoma

A. Hagenbeek 1* and V. Lewington 2

1 Department of Haematology, University Medical Center Utrecht, The Netherlands
2 Department of Nuclear Medicine and PET, Royal Marsden Hospital, Sutton, UK

* To whom correspondence should be addressed.
A. Hagenbeek, E-mail: a.hagenbeek{at}azu.nl


  Abstract

Background: Non-Hodgkin's lymphoma (NHL) comprises a group of related haematological malignancies, predominantly of B-cell origin, which have been described as indolent or aggressive according to their clinical course. Standard treatment for indolent NHL consists of conventional chemotherapy, but, although long-term remissions may occur, most patients will die of their disease. Radioimmunotherapy (RIT) is a novel modality for treating indolent NHL, using monoclonal antibodies to target tumour cells with systemic, low-dose radiation. 90Y-Ibritumomab tiuxetan (Zevalin®; Schering AG, Berlin, Germany), the first RIT approved for use in relapsed/refractory indolent NHL, comprises the murine anti-CD20 monoclonal antibody ibritumomab, covalently linked to the high-energy beta-emitter, yttrium-90, by the chelator, tiuxetan.

Materials and methods: A multidisciplinary consensus workshop of European clinicians who had taken part in clinical trials of 90Y-ibritumomab tiuxetan was convened to develop recommendations for the clinical preparation and administration of 90Y-ibritumomab tiuxetan in Europe. The workshop was held in anticipation of European Medicines Agency approval of this agent, which was gained in 2004 for adult patients with rituximab-relapsed or refractory CD20+ follicular B-cell NHL.

Results and conclusions: This article summarises the consensus recommendations developed for haemato-oncologists.

Keywords: guidelines; haematologist; lymphoma; oncologist; 90Y-ibritumomab tiuxetan.
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