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Annals of Oncology Advance Access published online on February 7, 2005
Annals of Oncology, doi:10.1093/annonc/mdi112
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© 2005 European Society for Medical Oncology
Received July 8, 2004
Revised November 2, 2004
Accepted November 15, 2004

Original article

Tumour-infiltrating gamma/delta T-lymphocytes are correlated with a brief disease-free interval in advanced ovarian serous carcinoma

M. R. Raspollini 1*, F. Castiglione 1, D. Rossi Degl'Innocenti 1, G. Amunni 2, A. Villanucci 2, F. Garbini 1, G. Baroni 1, and G. L. Taddei 1

1 Department of Human Pathology and Oncology, Perinatology and Reproductive Medicine, University of Florence, School of Medicine, Florence, Italy
2 Department of Gynecology, Perinatology and Reproductive Medicine, University of Florence, School of Medicine, Florence, Italy

* To whom correspondence should be addressed.
M. R. Raspollini, E-mail: mariarosaria.raspollini{at}unifi.it


  Abstract

Background: Significant progress has been made in understanding the molecular biology of ovarian carcinoma. Along with the molecular characteristics of cancer, the patient's response to the tumour may also contribute to survival; in particular, the effect of the immune system may play an important role on survival of cancer patients.

Patients and Methods: We analysed the CD3 positive tumour-infiltrating T cells and direct molecular assessment of T cell receptors (TCRs) gamma and beta in 95 advanced ovarian carcinomas.

Results: Gamma/delta T cells are statistically correlated with a brief disease-free interval (P=0.036). CD3 positive tumour-infiltrating T cells are correlated with a brief disease-free interval and with survival (P=0.004 and P=0.0001, respectively). CD3 positive tumour-infiltrating T cells are associated with clinical responsiveness to chemotherapy (P=0.003).

Conclusions: Further studies are required to better understand the role of gamma/delta T cells in ovarian carcinoma, yet these data underline the importance of host immune response to cancer and the need to better study immune mechanisms to modulate the therapeutic treatment of cancer.

Keywords: alpha; beta T cell, CD3, gamma; delta T cell, ovarian carcinoma, T cells.
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