Annals of Oncology 9:495-498, 1998
© 1998 European Society for Medical Oncology
research-article |
Clinico-pathological characterization of hepatitis C virus-related B-cell non-Hodgkin's lymphomas without symptomatic cryoglobulinemia
1Department of Medical Sciences, Section of Hematology, University of Modena Piacenza, Italy
2Department of Rheumatology, University of Modena Piacenza, Italy
3Hemodialysis Unit, University of Modena Piacenza, Italy
4First Department of Internal Medicine, Section of Hematology Piacenza, Italy
Correspondence to: Prof. Giuseppe Torelli Dipartimento di Scienze Mediche Sezione di Ematologia Universitá di Modena Policlinico Via del Pozzo 71 41100. Modena Italy
BACKGROUND: Epidemiological evidence has suggested an association between hepatitis C virus (HCV) infection and B-cell lymphoproliferation. We studied the prevalence of HCV infection in a series of de novo B-cell non-Hodgkin's lymphoma (B-NHL) cases and correlated virological findings with clin-ico-histological features.
PATIENTS AND METHODS: One hundred fifty-seven patients with de novo B-NHL were included in the study. Their serum was examined by ELISA and RIBA for the presence of anti-HCV antibodies, and either the peripheral blood mononuclear cells or the pathology tissues of all of the patients were examined by reverse transcriptase polymerase chain reaction for the presence of HCV RNA sequences.
RESULTS: HCV infection occurred in 22.3% of B-NHL patients and was documented before the diagnosis in about half of the positive cases. Of interest, HCV infection was more frequently found in follicular center, marginal zone and diffuse large-cell lymphoma types, but was not associated with symptomatic cryoglobulinemia. The median survival time was 48 months in HCV-positive and 52 months in HCV-negative B-NHL patients.
CONCLUSIONS: Our findings strengthen the pathogenetic link between HCV and B-NHL and show that HCV infection may be associated with the malignant proliferation of defined B-cell subsets other than the immunoglobulin Mk B-cell subset involved in the pathogenesis of mixed cryoglobulinemia type II and associated lymphoplasmacytoid lymphoma type. HCV-related liver disease did not affect the survival of our B-NHL patients.
B-cell non-Hodgkin's lymphoma, HCV, mixed cryoglobulinemia type II
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B Terrier, D Sene, D Saadoun, P Ghillani-Dalbin, V Thibault, A Delluc, J-C Piette, and P Cacoub Serum-free light chain assessment in hepatitis C virus-related lymphoproliferative disorders Ann Rheum Dis, January 1, 2009; 68(1): 89 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Saadoun, D. A. Landau, L. H. Calabrese, and P. P. Cacoub Hepatitis C-associated mixed cryoglobulinaemia: a crossroad between autoimmunity and lymphoproliferation Rheumatology, August 1, 2007; 46(8): 1234 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Visco, L Arcaini, E Brusamolino, S Burcheri, A Ambrosetti, M Merli, E Bonoldi, M Chilosi, A Viglio, M Lazzarino, et al. Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: analysis of 156 patients from northern Italy Ann. Onc., September 1, 2006; 17(9): 1434 - 1440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Suarez, O. Lortholary, O. Hermine, and M. Lecuit Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation Blood, April 15, 2006; 107(8): 3034 - 3044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Besson, D. Canioni, E. Lepage, S. Pol, P. Morel, P. Lederlin, A. Van Hoof, H. Tilly, P. Gaulard, B. Coiffier, et al. Characteristics and Outcome of Diffuse Large B-Cell Lymphoma in Hepatitis C Virus-Positive Patients in LNH 93 and LNH 98 Groupe d'Etude des Lymphomes de l'Adulte Programs J. Clin. Oncol., February 20, 2006; 24(6): 953 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D Cowgill, C. A Loffredo, S. A.-L. Eissa, N. Mokhtar, M. Abdel-Hamid, A. Fahmy, and G T. Strickland Case-control study of non-Hodgkin's lymphoma and hepatitis C virus infection in Egypt Int. J. Epidemiol., October 1, 2004; 33(5): 1034 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Morton, E. A. Engels, T. R. Holford, B. Leaderer, Y. Zhang, S. H. Zahm, P. Boyle, B. Zhang, S. Flynn, G. Tallini, et al. Hepatitis C Virus and Risk of Non-Hodgkin Lymphoma: A Population-Based Case-Control Study among Connecticut Women Cancer Epidemiol. Biomarkers Prev., March 1, 2004; 13(3): 425 - 430. [Abstract] [Full Text]
|
|
|
|
|
|
F. Giannelli, S. Moscarella, C. Giannini, P. Caini, M. Monti, L. Gragnani, R. G. Romanelli, V. Solazzo, G. Laffi, G. La Villa, et al. Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation Blood, August 15, 2003; 102(4): 1196 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Hermine, F. Lefrere, J.-P. Bronowicki, X. Mariette, K. Jondeau, V. Eclache-Saudreau, B. Delmas, F. Valensi, P. Cacoub, C. Brechot, et al. Regression of Splenic Lymphoma with Villous Lymphocytes after Treatment of Hepatitis C Virus Infection N. Engl. J. Med., July 11, 2002; 347(2): 89 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Germanidis, C. Haioun, J. Pourquier, P. Gaulard, J.-M. Pawlotsky, D. Dhumeaux, and F. Reyes Hepatitis C Virus Infection in Patients With Overt B-Cell Non-Hodgkin's Lymphoma in a French Center Blood, March 1, 1999; 93(5): 1778 - 1779. [Full Text] [PDF]
|
|