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Annals of Oncology 7:864-866, 1996
© 1996 European Society for Medical Oncology

brief-report

Synchronous multifocal osteosarcoma: Results in twelve patients treated with neoadjuvant chemotherapy and simultaneous resection of all involved bones

G. Bacci1,, P. Picci2, S. Ferrari1, M. Mercuri3, A. Briccoli5, D. Donati3, M. Manfrini3, A. Zanoni4, C. Forni1 and M. Campanacci3

1Sezione di Chemioterapia Bologna, Italy
2Laboratorio di Ricerca Oncologica Bologna, Italy
35a Divisione Ortopedica Bologna, Italy
4II Servizio Anestesia e Rianimozione, Istituti Ortopedici Rizzoli Bologna, Italy
5Istituto di Parologio Chirurgica, Universirà di Modena Modena, Italy

Correspondence to: Dr. Gaetano Bacci Sezione di Chemioterapia Istituti Ortopedici Rizzoli Via Pupilli 1 40136 Bologna Italy

BACKGROUND:: Multifocal osteosarcoma is a rare type of tumor which is always excluded from therapy trials and is therefore rarely investigated for prognosis and treatment.

PATIENTS AND METHODS:: Twelve patients with synchronous multifocal osteosarcoma underwent neoadjuvant chemotherapy and, when feasible, simultaneous resection of involved bones.

RESULTS:: Four patients were unsuitable for resection and died 5–13 months (average 9 months) later. In eight patients all lesions were resected simultaneously. Four patients are disease free at 15, 20, 24, and 60 months (average 29 months), and four relapsed and died at 12, 24, 30 and 36 months (average 30.5 months).

CONCLUSIONS:: Chemotherapy associated with aggressive surgery may be useful. The histological response of different lesions in the same patient are strongly correlated, confirming that synchronous multifocal osteosarcorna is not originally multicentric but unicentric with bone metastases.

bone sarcomas, chemotherapy, metastasis, multicentric, osteosarcoma, surgery


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