Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Tambussi, G.
Right arrow Articles by Badellino, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tambussi, G.
Right arrow Articles by Badellino, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Annals of Oncology 6:383-387, 1995
© 1995 European Society for Medical Oncology

research-article

Epidemic HIV-related Kaposi's sarcoma: A retrospective analysis and validation of TIS staging

G. Tambussi1,, L. Repetto2, V. Torri3, A. Saracco4, L. Moresco5, A. Antinori6, R. Zerboni7, A. Lazzarin1 and F. Badellino5,8

1Department of Infectious Diseases, Mario Negri Institute Milan
4Department of Epiunit, IRCCS San Raffaele, Mario Negri Institute Milan
3Laboratory of Biostatistics, Mario Negri Institute Milan
2Division of Medical Oncology, Istituto Nazionale per la Ricerca sul Cancro (1ST) Genova
5Division of Surgical Oncology, Istituto Nazionale per la Ricerca sul Cancro (1ST) Genova
6Department of Infectious Diseases, Catholic University Rome
7Department of Dermatology, University of Milan Milan, Italy
8Chairman Italian Committee for Cancer Classification (ICC)

Correspondence to: Giuseppe Tambussi, M.D., Department of Infectious Diseases, IRCCS San Raffaele, Via Stamira d'Ancona 20, 20152 Milano, Italy

BACKGROUND: We wished to assess the clinical value in terms of treatment choice and establishment of the prognosis of the ACTG classification modified (TNM-TIS) according to the recent guidelines of CDC for the classification of the HIV infection in patients with HIV-related epidemic Kaposi's sarcoma (EKS).

PATIENTS: We retrospectively studied 296 HIV-positive individuals with EKS. Patients were initially classified according to the NYU system and then reclassified according to the TNM-TIS proposal which considers three major parameters: T, anatomical extent of the lesion; I, immune system status; S, HIV-related systemic illness.

METHODS: Survival analyses according to patient characteristics and the different TNM-TIS classification stages were performed; curves were compared using the Kaplan-Meyer method, and predictive factors for survival using the Cox model.

RESULTS: Of the parameters considered in the TNM-TIS staging system, the T variable was not predictive of survival. Conversely, I and S variables revealed predictive value in the survival analyses, when considered separately and together.

CONCLUSIONS: The extent of cutaneous or mucosal lesions of Kaposi's sarcoma did not correlate with prognosis. However, both CD4+ cell count and history of systemic illness were predictive of survival. Indicators of HIV infection must be included in the clinical evaluation of EKS patients and taken into account when choosing optimal treatment.

epidemic Kaposi's sarcoma, HIV, staging, survival, TIS


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.