This article appears in the following Annals of Oncology issue: Expanding the boundaries of clinical practice: building on experience with targeted therapies 12 September 2008, Stockholm, Sweden [View the issue table of contents]
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Future developments in renal cell carcinoma
Solid Tumor Oncology (Genitourinary and Gastrointestinal) Section, Medical Oncology Service, Hospital Del Mar, Barcelona, Spain
Correspondence to: Joaquim Bellmunt, Solid Tumor Oncology (Genitourinary and Gastrointestinal), Medical Oncology Service, Hospital Del Mar, Paseo Maritimo 25–29, Barcelona 08003, Spain. Tel: +34-93-2483137 (2483611); Fax: +34-93-2483366; E-mail: jbellmunt{at}imas.imim.es
Background: The development of targeted agents has substantially improved prognoses for patients with metastatic renal cell carcinoma (mRCC). Four targeted agents are approved for the treatment of mRCC in Europe (bevacizumab given in combination with interferon-alfa, sorafenib, sunitinib and temsirolimus) and a number of investigational agents have shown potential in this setting.
Design: This report will review completed and ongoing clinical trials in mRCC designed to investigate the efficacy of targeted agents in sequential and combination therapies and in the adjuvant and neoadjuvant settings.
Results: A phase III trial, in which 71% of patients received prior sunitinib treatment, has indicated that everolimus can be used after sunitinib, the reference standard of care for first-line therapy, to extend progression-free survival. Phase I/II studies have provided preliminary data on the efficacy of sequential and combination therapies with targeted agents in mRCC. Several phase III studies investigating targeted agents in sequential and combination therapies and in the adjuvant and neoadjuvant settings are planned or ongoing, and data are awaited with interest.
Conclusions: Data suggest that sequential and combination therapies with targeted agents have potential in patients with mRCC. Ongoing research will help to optimise the use of targeted therapies in this setting.
Key words: clinical trials, metastatic renal cell carcinoma, sunitinib malate, targeted agents, tyrosine kinase inhibitor
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  C. N. Sternberg Expanding the boundaries of clinical practice: building on experience with targeted therapies Ann. Onc., May 1, 2009; 20(suppl_1): i1 - i6. [Abstract] [Full Text] [PDF]
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