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Annals of Oncology Advance Access originally published online on January 29, 2009
Annals of Oncology 2009 20(4):722-728; doi:10.1093/annonc/mdn691
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

hematologic malignancies

Characteristics of relapse after autologous stem-cell transplantation for follicular lymphoma: a long-term follow-up

M. Kornacker1, J. Stumm1, C. Pott2, S. Dietrich1, S. Süssmilch3, M. Hensel1, M. Nickelsen3, M. Witzens-Harig1, M. Kneba2, N. Schmitz3, A. D. Ho1 and P. Dreger1,*

1 Department of Medicine V, University of Heidelberg, Heidelberg
2 Department of Medicine II, University of Schleswig-Holstein, Kiel
3 Department of Hematology and Stem Cell Transplantation, Asklepios Klinik St Georg, Hamburg, Germany

* Correspondence to: Dr P. Dreger, Department of Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Tel: +49-6221-56-8008; Fax: +49-6221-56-6824; E-mail: peter.dreger{at}med.uni-heidelberg.de

Background: Pattern and outcome of disease recurrence after autologous stem-cell transplantation (autoSCT) for follicular lymphoma (FL) is not well known.

Patients and methods: Relapse cases were identified from 241 consecutive patients autografted for disseminated untransformed FL from 1990 to 2002 in three institutions. Prognostic factors for relapse and outcome after relapse were analyzed by log-rank comparisons and Cox regression analyses.

Results: One hundred and three relapses occurred. The 10-year relapse probability was 47%. Median time from autoSCT to relapse was 20 (2–128) months. Only three relapses were observed later than 6 years posttransplant. Median survival after relapse was 8.3 years. Patients with disease recurrence within 1 year from transplant and those who had received autoSCT as second-line treatment had significantly reduced survival by multivariate analysis, whereas Follicular Lymphoma International Prognostic Index score, age, remission status at autoSCT, high-dose regimen, and ex vivo purging had no impact.

Conclusions: FL recurrence after autoSCT follows a biphasic pattern with continuing relapse during the first 6 years and only few events thereafter. The prognosis after relapse is relatively good and appears to be comparable to that of disease recurrence after standard treatment. The situation is less favorable for patients who relapse within the first posttransplant year.

Key words: autologous stem-cell transplantation, follicular lymphoma, MRD, prognosis, relapse

Received for publication August 7, 2008. Revision received September 29, 2008. Accepted for publication October 1, 2008.


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