Annals of Oncology Advance Access originally published online on December 15, 2008
Annals of Oncology 2009 20(3):534-541; doi:10.1093/annonc/mdn643
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head and neck cancer |
Human papillomavirus 6 seropositivity is associated with risk of head and neck squamous cell carcinoma, independent of tobacco and alcohol use
1 Department of Environmental Health, Harvard School of Public Health, Boston
2 Department of Environmental Health, Boston University, Boston
3 Department of Vaccine and Biologics Research, Merck & Co., Inc., West Point
4 Department of Epidemiology and Cancer Center, University of Minnesota, Minneapolis
5 Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer; Institute, Boston
6 Division of Biology and Medicine, Department of Community Health and Laboratory Medicine and Pathology, Brown University, Providence, RI 02912, USA
* Correspondence to: Dr. K. T. Kelsey, Community Health and Pathology and Laboratory Medicine, Director, center for Environmental Health and Technology. Tel: 407-863-6420; Fax: 401-863-9008; Email: karl_kelsey{at}Brawn.edu
Background: The risk of head and neck squamous cell carcinoma (HNSCC) associated with common human papillomavirus types has not been well defined.
Methods: We conducted a case–control study of 1034 individuals (486 incident cases diagnosed with HNSCC and 548 population-based controls matched to cases by age, gender, and town of residence) in Greater Boston, MA. Sera were tested for antibodies to human papillomavirus (HPV)6, HPV11, HPV16, and HPV18 L1.
Results: HPV6 antibodies were associated with an increased risk of pharyngeal cancer [odds ratio (OR) = 1.6, 1.0–2.5], controlling for smoking, drinking, and HPV16 seropositivity. In HPV16-seronegative subjects, high HPV6 titer was associated with an increased risk of pharyngeal cancer (OR = 2.3, 1.1–4.8) and oral cancer (OR = 1.9, 1.0–3.6), suggesting that the cancer risk associated with HPV6 is independent of HPV16. There was no association between smoking and alcohol use and HPV6 serostatus. Further, the risk of pharyngeal cancer associated with heavy smoking was different among HPV6-seronegative (OR 3.1, 2.0–4.8) and HPV6-seropositive subjects (OR = 1.6, 0.7–3.5), while heavy drinking also appears to confer differing risk among HPV6-negative (OR 2.3, 1.5–3.7) and -positive subjects (OR = 1.3, 0.6–2.9).
Conclusions: There may be interactions between positive serology and drinking and smoking, suggesting that the pathogenesis of human papillomavirus in HNSCC involves complex interactions with tobacco and alcohol exposure.
Key words: epidemiology, head and neck squamous cell carcinoma, human papillomavirus, risk factors, serology
Received for publication March 6, 2008. Revision received August 20, 2008. Accepted for publication August 26, 2008.