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Annals of Oncology Advance Access originally published online on September 13, 2009
Annals of Oncology 2009 20(11):1899-1900; doi:10.1093/annonc/mdp422
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

letters to the editor

Essential thrombocythemia transforming into acute biphenotypic leukemia in a patient on hydroxyurea monotherapy

The first 10% of the full text of this article appears below.

We describe a rare event of acute biphenotypic leukemic (BAL) transformation of a patient with essential thrombocythemia (ET) being treated with hydroxyurea (HU).

Our patient was a 78-year-old African-American female who was diagnosed with ET in 1996. Her platelet count was 1500 x 109/l and bone marrow was diagnostic for ET. The same year she suffered a stroke. The patient received HU for the next 13 years and remained asymptomatic. In December 2009, she presented with a 2-week . . . [Full Text of this Article]

G. Sandhu1,*, A. Ranade2, S. Siddiqi1 and J. L. Balderacchi3

1 Department of Internal Medicine, St Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
2 Department of Pathology, St Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
3 Department of Hematopathology, St Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA

* (E-mail: gsandhu@chpnet.org)


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