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Annals of Oncology Advance Access originally published online on October 15, 2008
Annals of Oncology 2009 20(1):5-16; doi:10.1093/annonc/mdn532
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© The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

reviews

Treatment of the elderly colorectal cancer patient: SIOG expert recommendations

D. Papamichael1,*, R. Audisio2, J.-C. Horiot3, B. Glimelius4, J. Sastre5, E. Mitry6, E. Van Cutsem7, M. Gosney8, C.-H. Köhne9 and M. Aapro10

1 Department of Medical Oncology, B.O. C. Oncology Centre, Nicosia, Cyprus
2 Department of Surgery, Whiston Hospital, Prescot, UK
3 Centre de Lutte Contre le Cancer Georges-Francois Leclerc, Dijon, France
4 Akademiska Sjukhuset, Department of Oncology, Radiology and Clinical Immunology, University Hospital SE, Uppsala, Sweden
5 Servicio de Oncología Médica, Hospital Clinico San Carlos, Madrid, Spain
6 Service d'Hépato-gastroentérologie et Oncologie Digestive, CHU Ambroise Paré, Boulogne, France
7 Division of Digestive Oncology, University Hospital Gasthuisberg, Leuven, Belgium
8 The Institute of Health Sciences, University of Reading, Reading, UK
9 Klinik für Onkologie/Hämatologie, Klinikum Oldenburg, Oldenburg, Germany
10 SIOG office, Clinique de Genolier, Genolier, Switzerland

* Correspondence to: Dr D. Papamichael, Department of Medical Oncology, B.O.C. Oncology Centre, 32 Acropoleos Avenue, Strovolos 2006, Nicosia, Cyprus. Tel: +357-22-841306; Fax: +357-22-841306; E-mail: demetris.papamichael{at}bococ.org.cy

Colorectal cancer (CRC) is one of the commonest malignancies of Western countries, with approximately half the incidence occurring in patients >70 years of age. Elderly CRC patients, however, are understaged, undertreated and underrepresented in clinical trials. The International Society of Geriatric Oncology created a task force with a view to assessing the potential for developing guidelines for the treatment of elderly (geriatric) CRC patients. A review of the evidence presented by the task force members confirmed the paucity of clinical trial data in elderly people and the lack of evidence-based guidelines. However, recommendations have been proposed on the basis of the available data and on the emerging evidence that treatment outcomes for fit, elderly CRC patients can be similar to those of younger patients. It is hoped that these will pave the way for formal treatment guidelines based upon solid scientific evidence in the future.

Key words: chemotherapy, colorectal cancer, elderly, geriatric, radiotherapy, surgical management

Received for publication June 24, 2008. Accepted for publication June 27, 2008.


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