Skip Navigation


Annals of Oncology Advance Access originally published online on April 2, 2008
Annals of Oncology 2008 19(8):1465-1469; doi:10.1093/annonc/mdn122
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
19/8/1465    most recent
mdn122v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Theodore, C.
Right arrow Articles by Flechon, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Theodore, C.
Right arrow Articles by Flechon, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

urogenital tumors

A phase II multicenter study of oxaliplatin in combination with paclitaxel in poor prognosis patients who failed cisplatin-based chemotherapy for germ-cell tumors

C. Theodore1,*, C. Chevreau2, Y. Yataqhene3, K. Fizazi1, J. -P. Delord2, J. -P. Lotz4, L. Geoffrois5, P. Kerbrat6, V. Bui7 and A. Flechon8

1 Department of Medicine, Institut Gustave Roussy, Villejuif
2 Department of Medicine, Institut Claudius Regaud, Toulouse
3 Department of Oncology, Sanofi aventis pharmaceuticals Paris
4 Department of Medicine, Hopital Tenon, Paris
5 Department of Oncology, Centre Alexis Vautrin, Nancy
6 Department of Medicine, Centre Eugène. Marquis, Rennes
7 Department of Medicine, Institut Bergoniè, Bordeaux
8 Department of Medicine, Centre. Léon Bérard, Lyon, France

* Correspondence to: Dr C. A. Theodore, Institut Gustave Roussy—Medecine, rue camille desmoulins, Villejuif 94800, France. Tel: +33-142114898; Fax: +33-142115238; E-mail: c.theodore{at}hopital-foch.org

Background: The aim of this study is to determine feasibility and efficacy of the combination regimen oxaliplatin and paclitaxel in patients with cisplatin (CDDP)-refractory germ-cell tumors (GCT).

Patients and methods: Patients with either a cisplatin absolute-refractory GCT defined as progressive disease (PD) during or within 1 month of CDDP administration or with a poor prognosis relapse, defined as PD between the second and the sixth month after CDDP administration, were treated with a combination of oxaliplatin (130 mg/m2) and paclitaxel (175 mg/m2) administered every 21 days. Primary end point was efficacy.

Results: Twenty-seven patients were included. Patients were pretreated with a median of two lines of cisplatin-based chemotherapy (range 1–5). Sixteen patients were absolute refractory. Five patients had relapsed after high-dose chemotherapy plus stem-cell support. There were no complete responses but there was one marker-positive partial response and nine disease stabilization (34, 6%). After a median follow-up of 65 months, two patients are disease-free survivors. Main toxicity was leucocytopenia grade 3/4 in 30% of the patients.

Conclusion: Combination chemotherapy with oxaliplatin and paclitaxel is feasible with acceptable toxicity and may be effective if combined with additional treatment in patients with CDDP-refractory GCT.

Key words: cisplatin refractory, germ-cell tumors, oxaliplatin, paclitaxel

Received for publication January 6, 2008. Revision received February 28, 2008. Accepted for publication February 29, 2008.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.