Annals of Oncology Advance Access originally published online on May 13, 2008
Annals of Oncology 2008 19(6):1209-1210; doi:10.1093/annonc/mdn286
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COX-2 targeting in cancer: a new beginning?
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Cyclo-oxygenase-2 (COX-2), the inducible enzyme catalyzing the rate-limiting step in the conversion of arachidonic acid into eicosanoids, is overexpressed in a wide variety of malignancies and associates with poor prognostic features [1]. Consequently, selective COX-2 inhibitors have been explored as therapeutic or
Division of Medical Oncology, Regina Elena Cancer Center, Rome, Italy
* E-mail: alessandra.fabi@virgilio.it