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Annals of Oncology Advance Access originally published online on November 20, 2007
Annals of Oncology 2008 19(5):847-851; doi:10.1093/annonc/mdm528
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© The Author 2007. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

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Hepatic arterial infusion of chemotherapy: the role of diagnostic and interventional radiology

A. Ganeshan1, S. Upponi1, Lye-quen Hon2, D. Warakaulle3 and R. Uberoi1,*

1 Department of Radiology, John Radcliffe Hospital, Headley Way, Oxford
2 Department of Radiology, The Royal Hallamshire Hospital, Glossop Road, Sheffield
3 Stoke Mandeville Hospital, Mandeville Road, Aylesbury, UK

* Correspondence to: Dr R. Uberoi, Department of Radiology, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Tel: +44-1865-220816; Fax: +44-1865-220801; E-mail: raman.uberoi{at}orh.nhs.uk

Hepatic arterial infusion of chemotherapy (HAIC) delivers higher local drug concentration to unresectable liver tumors with fewer significant systemic side-effects. It has been shown to produce better response rates than systemic chemotherapy and remains an important treatment option in patients with advanced, inoperable primary or maetastatic hepatic tumors. Traditionally, catheters for HAIC were inserted surgically under general anesthesia. The advancement and expansion of interventional radiology have made it possible for catheter-port systems to be inserted percutnaeously under local anesthesia with no significant increase in morbidity. A comprehensive review of the literature, techniques and complications of percutanoeus placement of catheter-port systems for HAIC is presented in this article.

Key words: chemotherapy, colorectal cancer, HAIC, hepatic arterial infusion

Received for publication September 7, 2007. Revision received October 12, 2007. Accepted for publication October 15, 2007.


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