Skip Navigation


Annals of Oncology Advance Access originally published online on December 6, 2007
Annals of Oncology 2008 19(2):327-331; doi:10.1093/annonc/mdm495
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
19/2/327    most recent
mdm495v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Prat, A.
Right arrow Articles by Del Campo, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prat, A.
Right arrow Articles by Del Campo, J. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 European Society for Medical Oncology. For Permissions, please email: journals.permissions@oxfordjournals.org

gynecologic tumors

Nadir CA-125 concentration in the normal range as an independent prognostic factor for optimally treated advanced epithelial ovarian cancer

A. Prat1,*, M. Parera1, S. Peralta1, M. A. Perez-Benavente2, A. Garcia3, A. Gil-Moreno2, J. M. Martinez-Palones2, I. Roxana1, J. Baselga1 and J. M. Del Campo1

1 Department of Medical Oncology
2 Department of Gynecologic Oncology
3 Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain

* Correspondence to: Dr A. Prat, Department of Medical Oncology, Vall d'Hebron University Hospital, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain. Tel: +34-93-489-30-00; Fax:+34-93-274-60-59; E-mail: alprat{at}vhebron.net

Background: The amount of residual disease after surgery is considered the most important factor influencing the survival of patients with advanced epithelial ovarian cancer (adEOC). In optimally treated patients with adEOC, there are no well-established prognostic factors [excluding International Federation of Gynecology and Obstetrics (FIGO) stage]. The aim of this retrospective study is to analyze the prognostic value of the CA-125 nadir after the completion of an optimal primary treatment.

Patients and methods: Patients treated for adEOC were identified from January 1998 to December 2006. Inclusion criteria: elevated CA-125 at time of diagnosis (>35 kU/l); FIGO stage III–IV treated with optimal primary treatment (residual tumor <1 cm and carboplatin/taxane-based combination chemotherapy); and complete response to optimal primary treatment with normalization of CA-125.

Results: Patients, n = 96: 44 group A (≤10 kU/l); 52 group B (11–35 kU/l). Median progression-free survival (PFS) was 42 and 20 months for groups A and B, respectively (P = 0.0087). Median overall survival (OS) was 84 and 43 months for groups A and B, respectively (P < 0.0001). The Cox model showed a highly significant impact on PFS and OS in relation to CA-125 nadir levels.

Conclusions: The CA-125 nadir value is a strong independent prognostic factor for optimally treated adEOC after achieving a complete response.

Key words: CA-125 nadir, carboplatin, ovarian cancer, paclitaxel, prognostic factor

Received for publication June 9, 2007. Revision received August 14, 2007. Accepted for publication September 14, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JCOHome page
A. Prat, M. Parera, and J. M. Del Campo
Prognostic Role of CA-125 Nadir in Stage IV Epithelial Ovarian Cancer
J. Clin. Oncol., April 1, 2008; 26(10): 1771 - 1772.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.