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Annals of Oncology Advance Access originally published online on October 24, 2007
Annals of Oncology 2008 19(2):276-283; doi:10.1093/annonc/mdm491
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© 2007 European Society for Medical Oncology. For Permissions, please email: journals.permissions@oxfordjournals.org

breast cancer

Population-based study of breast cancer survival in Cote d'Or (France): prognostic factors and relative survival

T. S. Dabakuyo1,5, F. Bonnetain1,5, P. Roignot2, M.-L. Poillot1,5, G. Chaplain1, T. Altwegg3, G. Hedelin4 and P. Arveux1,5,*

1 Breast and Gynaecologic Cancer Registry of Cote d'Or, Centre Georges François Leclerc, 1 rue Professeur Marion, Dijon
2 Centre de Pathologie, 33 rue Nicolas Bornier, Dijon
3 Centre Radiotherapie Du Parc, 18 cours du General de Gaulle, Dijon
4 Department of Epidemiology and Public Health, Faculty of Medicine, Louis Pasteur University, 11 rue Humann, Strasbourg
5 EA 4184, Faculty of Medicine, University of Burgundy, 7 boulevard Jeanne d'Arc, Dijon, France

* Correspondence to: Dr P. Arveux, Centre Georges-François Leclerc, 1 rue Professeur Marion, Dijon 21000, France. Tel: +33-03-80-73-77-15; Fax: +33-03-80-73-77-34; E-mail: parveux{at}dijon.fnclcc.fr

Background: Few population-based studies have reported jointly analyses of relative survival according to the following prognostic factors: tumour–node–metastasis (TNM) stage, age, number of examined and positive nodes, hormonal status, histological Scarff, Bloom and Richardson (SBR) grade, tumour extension, hormone receptor status and tumour multifocal status.

Patients and methods: Data on female invasive breast cancer were provided by the Cote d'Or breast cancer registry. The Kaplan–Meier method and log-rank test were used to estimate and compare the survival probability at 1, 5, 10 and 15 years. The effect of prognostic factors on survival was assessed with crude and relative multivariate survival analyses.

Results: Crude survival seemed to be worse in patients aged >60 years compared with those aged 45–60 (P > 0.0001), whereas relative survival did not differ. TNM stage, histological SBR grade, progesterone receptor status, tumour multifocal status, locoregional extension and the period of diagnosis were independent prognostic factors of crude and relative survival.

Conclusion: Breast cancer is influenced by many factors. Despite the absence of any association between the number of examined nodes and overall survival in this study, the number of nodes removed, in conjunction with other prognostic factors, may be useful in selecting node-negative patients for systemic therapy.

Key words: breast cancer, crude survival, epidemiology, population-based cancer registry, prognostic factors, relative survival

Received for publication May 31, 2007. Revision received September 19, 2007. Accepted for publication September 19, 2007.


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