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Annals of Oncology Advance Access originally published online on September 14, 2007
Annals of Oncology 2008 19(2):223-232; doi:10.1093/annonc/mdm352
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© 2007 European Society for Medical Oncology. For Permissions, please email: journals.permissions@oxfordjournals.org

reviews

HER-2 overexpression/amplification and its interaction with taxane-based therapy in breast cancer

E. Azambuja1,2,3, V. Durbecq1,2, D. D. Rosa1,2, M. Colozza4, D. Larsimont1,2, M. Piccart-Gebhart1,2 and F. Cardoso1,2,*

1 Departments of Medical Oncology and Translational Research Unit—Jules Bordet Institute, Brussels
2 L'Université Libre de Bruxelles (ULB), Brussels, Belgium
3 Ciências Médicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
4 S.C. Oncologia Medica, Azienda Ospedaliera, San Sisto 06132 Perugia, Italy

* Correspondence to: Dr F. Cardoso, MD, Jules Bordet Institute, Boulevard de Waterloo, 125, 1000 Brussels, Belgium. Tel: +32-2-541-3082; Fax: +32-2-541-0858; E-mail: fatima.cardoso{at}bordet.be

Breast cancer (BC) is the most common cancer in women and it is incurable when metastases are diagnosed. Taxanes, namely docetaxel and paclitaxel, are effective chemotherapeutic agents in the metastatic, neoadjuvant and adjuvant settings. HER-2 overexpression/amplification is detected in 25–30% of BCs and confers aggressive tumor behavior as well as resistance to some systemic treatments; nevertheless, its association with response to taxane-based chemotherapy is still unclear, with conflicting results in both in vitro and in vivo preclinical studies. This review will address the impact of HER-2 overexpression/amplification in BC patients treated with taxanes. Prospective, randomized trials incorporating important biological hypotheses are either ongoing or just closed, and their results will hopefully help to shed more light on this issue.

Key words: breast cancer, ECD, HER-2 overexpression, taxane resistance, trastuzumab

Received for publication March 8, 2007. Revision received June 7, 2007. Accepted for publication June 8, 2007.


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