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Annals of Oncology 2007 18(9):1518-1522; doi:10.1093/annonc/mdm200
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© 2007 European Society for Medical Oncology

gastrointestinal tumors

Participation in screening colonoscopy in first-degree relatives from patients with colorectal cancer

F Ruthotto1, F Papendorf2, G Wegener2, G Unger3, B Dlugosch3, F Korangy1, MP Manns1 and TF Greten1,*

1 Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover
2 Cancer Center, Medizinische Hochschule Hannover
3 Kassenärztliche Vereinigung Niedersachsen, Hannover, Germany

* Correspondence to: Prof. T. F. Greten, Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Carl-Neuberg Str. 1, 30625 Hannover, Germany. Tel: 49-511-532 8941; Fax: 49-511-532 8945; E-mail: greten.tim{at}mh-hannover.de

Background: Current guidelines recommend screening colonoscopy in first-degree relatives of patients with colon cancer. The aim of this state-wide study was to investigate the compliance for colonoscopic in first-degree relatives, who were younger than 60 years of age.

Methods: A total of 602 patients were identified from the tumor registry of the public health insurance of Lower Saxony. A questionnaire was sent to these patients, which included a number of different questions regarding their knowledge about the risk of colon cancer for their family members, as well as their participation in screening colonoscopy.

Results: Data from 442 patients and their first-degree relatives (1005 siblings and 354 parents) were available; 178 parents had undergone screening colonoscopy and 344 siblings. Interestingly, the percentage of siblings who underwent screening colonoscopy was significantly higher (27%) among those siblings where the index patients were aware of the increased risk for the first-degree relatives, in contrast to the siblings of the index patients who were not aware of this risk (20%).

Conclusion: This study demonstrates that only a minority of first-degree relatives undergo screening colonoscopy and that informing patients about the potential risk for their relatives will increase participation in screening colonoscopy in first-degree relatives of the patients.

Key words: colon cancer, colonoscopy, family history, screening

Received for publication February 16, 2007. Revision received April 14, 2007. Accepted for publication April 17, 2007.


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