© 2007 European Society for Medical Oncology
letters to the editor |
Vascular disrupting therapy-induced mobilization of circulating endothelial progenitor cells
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Antivascular therapies are currently intensively studied approaches in clinical oncology. Low molecular weight vascular disrupting agents (VDA) aim to cause rapid and selective shutdown of the established tumor vasculature, leading to massive cancer cell death in the central areas of tumor [1]. However, a common feature of VDA that is poorly understood is the sparing of a relatively intact viable rim at the periphery of the tumor. This viable rim leads to rapid regrowth of tumors
1 Translational Research Laboratory, Gustave Roussy Institute, 94805 Villejuif, France
2 Department of Medicine, Gustave Roussy Institute
3 Sanofi Aventis, 92165 Antony, France
* E-mail: soria@igr.fr