Annals of Oncology Advance Access originally published online on April 10, 2007
Annals of Oncology 2007 18(7):1260-1267; doi:10.1093/annonc/mdm092
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2007 European Society for Medical Oncology
supportive care |
Familial blood vessel tumors and subsequent cancers
1 Center for Family and Community Medicine, Karolinska Institute, 141 83 Huddinge, Sweden
2 Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
* Correspondence to: Dr J. Ji, Center for Family and Community Medicine, Karolinska Institute, 141 83 Huddinge, Sweden. Tel: +46-8-524-88671; Fax: +46-8-524-88706; E-mail: jianguang.ji{at}ki.se
Background: Population-based data on the familial risk for vascular tumors are largely lacking. Such data are important for clinical counseling and cancer genetics.
Methods: We used the Swedish Family-Cancer Database to calculate standardized incidence ratios for specific subtypes of vascular tumors in offspring using parents as probands. In addition, risks for second cancers were analyzed.
Results: Offspring hemangioblastoma in the nervous system was associated with parental kidney cancer and nervous system hemangioblastoma and hemangioma. Offspring nervous system hemangiopericytoma was associated with parental pituitary adenomas. Offspring angiosarcoma in the trunk and extremities was associated with maternal breast cancer. Second Kaposi's sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease and myeloma were increased following primary skin Kaposi's sarcoma. Kidney and endocrine gland tumors and nervous system hemangioblastomas and hemangiomas were in excess following primary nervous system hemangioblastoma and hemangioma.
Conclusions: Our data showed that familial clustering of nervous system hemangioblastoma and hemangioma and the risks of subsequent cancers were primarily related to von-Hippel-Lindau disease. As a novel association, offspring nervous system hemangiopericytomas were in excess when parents were diagnosed with pituitary adenoma. Similarly, offspring angiosarcoma is associated with maternal breast cancer. Immunodeficiency may explain the excess of lymphoproliferative diseases after skin Kaposi's sarcoma.
Key words: blood vessel tumors, familial risk, hemangioblastoma, hemangioma, Kaposi's sarcoma
Received for publication September 14, 2006. Revision received December 13, 2006. Accepted for publication February 13, 2007.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Hemminki, P. Lenner, J. Sundquist, and J. Lorenzo Bermejo Risk of Subsequent Solid Tumors After Non-Hodgkin's Lymphoma: Effect of Diagnostic Age and Time Since Diagnosis J. Clin. Oncol., April 10, 2008; 26(11): 1850 - 1857. [Abstract] [Full Text] [PDF]
|
|