Annals of Oncology Advance Access originally published online on February 16, 2007
Annals of Oncology 2007 18(4):722-729; doi:10.1093/annonc/mdl491
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© 2007 European Society for Medical Oncology
gynecologic tumors |
Hemoglobin variation and blood transfusion rates in patients affected by locally advanced cervical cancer undergoing neo-adjuvant chemotherapy followed by radical surgery: the role of erythropoietic growth factors
1 Department of Gynecology, Obstetrics and Perinatology, University of Rome ‘La Sapienza’
2 Department of Gynecology and Obstetrics, University of Rome ‘Campus BioMedico’, Rome, Italy
* Correspondence to: Dr P. Benedeth Panici, Department of Gynecology and Obstetrics, University of Rome ‘La Sapienza’, V.le Regina Elena 324, 00161 Rome, Italy. Tel: +39-3394774328; Fax +39-06-49972615; E-mail: pierluigi.benedettipanici{at}uniroma1.it
Background: The objectives of the present study were to evaluate hemoglobin levels and consequent clinical behaviors related to anemia developed in patients affected by locally advanced cervical cancer treated with neo-adjuvant chemotherapy in the last decade and to evaluate the impact that the introduction of erythropoietic growth factors had in the clinical practice.
Patients and methods: Blood chemistries, prospectively recorded from 98 cervical cancer patients, treated with neo-adjuvant chemotherapy and, if necessary, erythropoietic growth factors, were compared with matched historical controls before the introduction of growth factors in clinical practice.
Results: Hemoglobin level in the study group did not differ significantly during chemotherapy. At the third cycle of chemotherapy and at the end of chemotherapy, hemoglobin level was significantly higher in the study group compared with the control group. Transfusion rates in the study group were significantly lower. The analysis within the study group revealed that hemoglobin level in patients who suffer at diagnosis from anemia tends to increase whereas hemoglobin level in nonanemic patients tends to decrease.
Conclusions: Erythropoietic growth factors increase hemoglobin level and reduce blood transfusions in cervical cancer patients undergoing neo-adjuvant chemotherapy followed by radical surgery. An appropriate autologous blood donation program can noticeably reduce homologous blood transfusions.
Key words: blood transfusions, erythropoietic growth factors, locally advanced cervical cancer, neo-adjuvant chemotherapy
Received for publication June 15, 2006. Revision received December 7, 2006. Accepted for publication December 11, 2006.
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