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Annals of Oncology Advance Access originally published online on January 17, 2007
Annals of Oncology 2007 18(2):211-212; doi:10.1093/annonc/mdl480
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© 2007 European Society for Medical Oncology

editorials

Follow-up of successfully treated testicular cancer patients: consequences of the metabolic syndrome

EC de Haas, D. Th. Sleijfer and JA Gietema*

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, The Netherlands

* E-mail: j.a.gietema@int.umcg.nl

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The first reports on the long-term follow-up of testicular cancer patients, including long-term treatment-related toxicity, originate from the late 1980s. Several of these papers report on cardiovascular disease, in particular myocardial infarction and coronary artery disease, after treatment with cisplatin-based chemotherapy [1–3]. With prolonged follow-up and a growing number of these survivors, there is increasing evidence that both chemotherapy and radiotherapy are associated with an increased long-term risk of cardiovascular disease, compared with treatment with orchidectomy only [4–6] and with the general male background population [6, 7]. Development of cardiovascular disease together with secondary malignancies belongs to the most important long-term risks for . . . [Full Text of this Article]


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