Annals of Oncology Advance Access originally published online on August 22, 2007
Annals of Oncology 2007 18(10):1685-1690; doi:10.1093/annonc/mdm265
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2007 European Society for Medical Oncology
hematologic malignancies |
FDG-PET in T-cell and NK-cell neoplasms
1 Department of Hematology & Oncology
2 Department of Dermatology
3 Department of Radiology, Graduate School of Medicine, University of Tokyo
4 Department of Pathology, Toranomon Hospital, Tokyo, Japan
* Correspondence to: Mineo Kurokawa, Department of Hematology & Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Tel: +81-3–5800–9092; fax: +81-3–5840–8667; e-mail address: kurokawa-tky{at}umin.ac.jp.
Background: A growing number of studies demonstrate the utility of 18fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in the management of malignant lymphoma. The results of FDG-PET, however, have not been studied extensively for T-cell and natural killer (NK)-cell neoplasms.
Patients and methods: We retrospectively evaluated pretreatment FDG-PET scans in 41 patients with T/NK-cell neoplasms diagnosed according to the World Health Organization (WHO) classification. Histological subtypes frequently included were peripheral T-cell lymphoma, unspecified (PTCLu, n = 11), extranodal NK/T-cell lymphoma, nasal type (ENKL, n = 8), primary cutaneous anaplastic large cell lymphoma (C-ALCL, n = 5), and angioimmunoblastic T-cell lymphoma (AILT, n = 4).
Results: FDG-PET detected a lymphoma lesion in at least one site in 36 out of 41 patients. The positive rate was equally high in most histological subtypes except for cutaneous lymphomas: PTCLu 91%, ENKL 100%, C-ALCL 60%, AILT 100%. All the patients without an FDG-avid lesion had lesions restricted to skin. Among patients who had cutaneous lesions, only 50% had FDG-avid cutaneous lesions, all of which were tumorous. The positive rate of FDG-PET for bone marrow involvement was only 20%.
Conclusion: T/NK-cell neoplasms incorporated in this study were generally FDG-avid except for cutaneous lesions and bone marrow involvement.
Key words: FDG-PET, T/NK-cell neoplasms, cutaneous lesions
Received for publication February 13, 2007. Revision received April 21, 2007. Accepted for publication April 27, 2007.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  H. J. Otero, J. P. Jagannathan, L. M. Prevedello, C. J. Johnston, N. H. Ramaiya, A. D. Van den Abbeele, and P. J. DiPiro CT and PET/CT Findings of T-Cell Lymphoma Am. J. Roentgenol., August 1, 2009; 193(2): 349 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-y. Au, D. D. Weisenburger, T. Intragumtornchai, S. Nakamura, W.-S. Kim, I. Sng, J. Vose, J. O. Armitage, R. Liang, and for the International Peripheral T-Cell Lymphoma P Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project Blood, April 23, 2009; 113(17): 3931 - 3937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Seam, M. E. Juweid, and B. D. Cheson The role of FDG-PET scans in patients with lymphoma Blood, November 15, 2007; 110(10): 3507 - 3516. [Abstract] [Full Text] [PDF]
|
|